TY - JOUR
T1 - V1a receptor knockout mice exhibit impairment of spatial memory in an eight-arm radial maze
AU - Egashira, Nobuaki
AU - Tanoue, Akito
AU - Higashihara, Fuminori
AU - Mishima, Kenichi
AU - Fukue, Yoshihiko
AU - Takano, Yukio
AU - Tsujimoto, Gozoh
AU - Iwasaki, Katsunori
AU - Fujiwara, Michihiro
PY - 2004/2/19
Y1 - 2004/2/19
N2 - In this study, we examined the performance of vasopressin V1a receptor (V1aR) and vasopressin V1b receptor (V1bR) knockout (KO) mice compared to wild-type (WT) mice in an eight-arm radial maze. V1aR KO mice exhibited an impairment of spatial memory in comparison to WT mice. By contrast, we did not observe any significant differences between the V1bR KO mice and the WT mice in the eight-arm radial maze. Moreover, OPC-21268, a selective V1aR antagonist, impaired spatial memory in the eight-arm radial maze in WT mice characterized by an increased number of errors. These results suggest that the V1aR controls spatial memory in mice.
AB - In this study, we examined the performance of vasopressin V1a receptor (V1aR) and vasopressin V1b receptor (V1bR) knockout (KO) mice compared to wild-type (WT) mice in an eight-arm radial maze. V1aR KO mice exhibited an impairment of spatial memory in comparison to WT mice. By contrast, we did not observe any significant differences between the V1bR KO mice and the WT mice in the eight-arm radial maze. Moreover, OPC-21268, a selective V1aR antagonist, impaired spatial memory in the eight-arm radial maze in WT mice characterized by an increased number of errors. These results suggest that the V1aR controls spatial memory in mice.
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U2 - 10.1016/j.neulet.2003.11.050
DO - 10.1016/j.neulet.2003.11.050
M3 - Article
C2 - 15036628
AN - SCOPUS:0442307844
SN - 0304-3940
VL - 356
SP - 195
EP - 198
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 3
ER -