TY - JOUR
T1 - Usefulness of perfusion- and diffusion-weighted imaging to differentiate between pilocytic astrocytomas and high-grade gliomas
T2 - a multicenter study in Japan
AU - Kikuchi, Kazufumi
AU - Hiwatashi, Akio
AU - Togao, Osamu
AU - Yamashita, Koji
AU - Kamei, Ryotaro
AU - Kitajima, Mika
AU - Kanoto, Masafumi
AU - Takahashi, Hiroto
AU - Uchiyama, Yusuke
AU - Harada, Masafumi
AU - Shinohara, Yuki
AU - Yoshiura, Takashi
AU - Wakata, Yuki
AU - Honda, Hiroshi
N1 - Funding Information:
Funding This study was funded by Bayer Yakuhin Ltd. The study data were independently analyzed and interpreted by the funder.
Publisher Copyright:
© 2018, Springer-Verlag GmbH Germany, part of Springer Nature.
PY - 2018/4/1
Y1 - 2018/4/1
N2 - Purpose: Imaging findings of pilocytic astrocytoma (PA) vary widely, sometimes resembling those of high-grade glioma (HGG). This study aimed to identify the imaging parameters that can be used to differentiate PA from HGG. Methods: Altogether, 60 patients with PAs and 138 patients with HGGs were included in the study. Tumor properties and the presence of hydrocephalus, peritumoral edema, and dissemination were evaluated. We also measured the maximum relative cerebral blood flow (rCBFmax) and volume (rCBVmax) and determined the minimum apparent diffusion coefficient (ADCmin) in the tumor’s solid components. The relative T1 (rT1), T2 (rT2), and contrast-enhanced T1 (rCE-T1) intensity values were evaluated. Parameters were compared between PAs and HGGs using the Mann–Whitney U test. Receiver operating characteristic (ROC) curve analysis was also used to evaluate these imaging parameters. A value of P <.05 was considered to indicate significance. Results: Intratumoral hemorrhage and calcification were observed in 10.0% and 21.7% of PAs, respectively. The rCBFmax and rCBVmax values were significantly lower in PAs (0.50 ± 0.35, 1.82 ± 1.21) than those in HGGs (2.98 ± 1.80, 9.54 ± 6.88) (P <.0001, P =.0002, respectively). The ADCmin values were significantly higher in PAs (1.36 ± 0.56 × 10−3 mm2/s) than those in HGGs (0.86 ± 0.37 × 10−3 mm2/s) (P <.0001). ROC analysis showed that the best diagnostic performance was achieved with rCBFmax. Conclusion: The rCBFmax, rCBVmax, and ADCmin can differentiate PAs from HGGs.
AB - Purpose: Imaging findings of pilocytic astrocytoma (PA) vary widely, sometimes resembling those of high-grade glioma (HGG). This study aimed to identify the imaging parameters that can be used to differentiate PA from HGG. Methods: Altogether, 60 patients with PAs and 138 patients with HGGs were included in the study. Tumor properties and the presence of hydrocephalus, peritumoral edema, and dissemination were evaluated. We also measured the maximum relative cerebral blood flow (rCBFmax) and volume (rCBVmax) and determined the minimum apparent diffusion coefficient (ADCmin) in the tumor’s solid components. The relative T1 (rT1), T2 (rT2), and contrast-enhanced T1 (rCE-T1) intensity values were evaluated. Parameters were compared between PAs and HGGs using the Mann–Whitney U test. Receiver operating characteristic (ROC) curve analysis was also used to evaluate these imaging parameters. A value of P <.05 was considered to indicate significance. Results: Intratumoral hemorrhage and calcification were observed in 10.0% and 21.7% of PAs, respectively. The rCBFmax and rCBVmax values were significantly lower in PAs (0.50 ± 0.35, 1.82 ± 1.21) than those in HGGs (2.98 ± 1.80, 9.54 ± 6.88) (P <.0001, P =.0002, respectively). The ADCmin values were significantly higher in PAs (1.36 ± 0.56 × 10−3 mm2/s) than those in HGGs (0.86 ± 0.37 × 10−3 mm2/s) (P <.0001). ROC analysis showed that the best diagnostic performance was achieved with rCBFmax. Conclusion: The rCBFmax, rCBVmax, and ADCmin can differentiate PAs from HGGs.
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U2 - 10.1007/s00234-018-1991-7
DO - 10.1007/s00234-018-1991-7
M3 - Article
C2 - 29450601
AN - SCOPUS:85042113697
SN - 0028-3940
VL - 60
SP - 391
EP - 401
JO - Neuroradiology
JF - Neuroradiology
IS - 4
ER -