TY - JOUR
T1 - Upregulation of NMDA receptor subunit proteins in the cerebral cortex during diazepam withdrawal
AU - Tsuda, Makoto
AU - Chiba, Yoshihiko
AU - Suzuki, Tsutomu
AU - Misawa, Miwa
N1 - Funding Information:
This work was supported in part by a Grant-in-Aid from The Tokyo Biochemical Research Foundation and a Research Grant (8A-5) for Nervous and Mental Disorders from the Ministry of Health and Welfare to T.S.
PY - 1998/1/12
Y1 - 1998/1/12
N2 - The present study investigated the changes in NMDA receptor subunit proteins in diazepam-withdrawn rat cerebral cortex, using Western blotting analysis. The protein levels of the NR1 and NR2B, but not NR2A, subunits were significantly increased in diazepam-withdrawn rats compared to those in control rats. Therefore, an increase in the NR1 and NR2B subunit proteins may be responsible for both the previously observed upregulation of [3H]dizocilpine binding in the cerebral cortex and the appearance of diazepam withdrawal signs.
AB - The present study investigated the changes in NMDA receptor subunit proteins in diazepam-withdrawn rat cerebral cortex, using Western blotting analysis. The protein levels of the NR1 and NR2B, but not NR2A, subunits were significantly increased in diazepam-withdrawn rats compared to those in control rats. Therefore, an increase in the NR1 and NR2B subunit proteins may be responsible for both the previously observed upregulation of [3H]dizocilpine binding in the cerebral cortex and the appearance of diazepam withdrawal signs.
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U2 - 10.1016/S0014-2999(97)01501-X
DO - 10.1016/S0014-2999(97)01501-X
M3 - Article
C2 - 9543260
AN - SCOPUS:0032509818
SN - 0014-2999
VL - 341
SP - R1
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
IS - 2-3
ER -