Upregulation of cytochrome p450s following exposure of the silkmoth, Bombyx mori to insecticides

Kohji Yamamoto, Hirofumi Ichinose, Yoichi Aso, Miyako Udono, Yoshinori Katakura

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


We examined which proteins were enhanced in the silkmoth in response to its exposure to insecticides. We previously found that the levels of four cytochrome P450s (CYPs) were higher following insecticide exposure (Yamamoto et al., 2010). In this study, we focused on other mRNAs encoding the silkmoth CYP proteins (CYP6B29, CYP18A1, CYP366A1, CYP302A1) induced. mRNA expression analysis revealed that each CYP mRNA was expressed in a tissue-specifc manner and that expression was developmentally regulated. Quantitative PCR revealed that these CYP mRNAs were upregulated in the larval fat body after exposure of the silkmoth to various insecticides. Our results suggest that the CYPs can contribute to insecticide resistance in Lepidopterans.

Original languageEnglish
Pages (from-to)33-38
Number of pages6
JournalJournal of Insect Biotechnology and Sericology
Issue number2
Publication statusPublished - 2013

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Applied Microbiology and Biotechnology
  • General Business,Management and Accounting
  • General Agricultural and Biological Sciences
  • Insect Science
  • Industrial and Manufacturing Engineering


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