Up-regulation of Nrf-2 and nqo1 expression by bidens pilosa extract in human keratinocytes

Masakazu Takahara, Kazuyo Kita, Konosuke Nagae, Akiko Hachiya, Ran Hidaka, Tomoyo Isotani, Kazuko Doi, Kenjiro Takei, Masutaka Furue

Research output: Contribution to journalArticlepeer-review


Bidens pilosa extract has an antioxidative effect and has recently been used for the treatment of livedo vasculopathy as a folk medicine. We investigated the effects of Bidens pilosa extract on human cultured keratinocytes. Bidens pilosa extract induced nuclear translocation of aryl hydrocarbon receptor from cytoplasm. The AhR activation up-regulated anti-oxidative signaling pathways such as nuclear factor-erythroid-2-related factor-2 and NAD(P)H: quinone oxidoreductase 1. These findings may explain, at least in part, the anti-oxidative mechanism of Bidens pilosa extract.

Original languageEnglish
Pages (from-to)230-233
Number of pages4
JournalNishinihon Journal of Dermatology
Issue number3
Publication statusPublished - 2013

All Science Journal Classification (ASJC) codes

  • Dermatology


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