Unexpectedly large water-proton relaxivity of TEMPO incorporated into micelle-oligonucleotides

Emi Tanimoto; Satoru Karasawa; Shoji Ueki; Nobuhiro Nitta; Ichio Aoki; Noboru Koga

doi:10.1039/c3ra22372h

Unexpectedly large water-proton relaxivity of TEMPO incorporated into micelle-oligonucleotides

Emi Tanimoto, Satoru Karasawa, Shoji Ueki, Nobuhiro Nitta, Ichio Aoki, Noboru Koga

Chemo-Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

Three lipid-oligonucleotides (ODN) carrying TEMPO were prepared and formed a micelle with a diameter of ca. 10 nm. The double strand ODN, lipid-polyT _inDS, incorporating TEMPO near the core of the micelle showed the largest water-proton relaxivity, r₁, value of 2.4 (25 MHz, 0.59 T) and 6.8 mM^-1 s^-1 (42 MHz, 1.0 T) per TEMPO.

Original language	English
Pages (from-to)	3531-3534
Number of pages	4
Journal	RSC Advances
Volume	3
Issue number	11
DOIs	https://doi.org/10.1039/c3ra22372h
Publication status	Published - Mar 21 2013

All Science Journal Classification (ASJC) codes

Chemistry(all)
Chemical Engineering(all)

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abstract = "Three lipid-oligonucleotides (ODN) carrying TEMPO were prepared and formed a micelle with a diameter of ca. 10 nm. The double strand ODN, lipid-polyT inDS, incorporating TEMPO near the core of the micelle showed the largest water-proton relaxivity, r1, value of 2.4 (25 MHz, 0.59 T) and 6.8 mM-1 s-1 (42 MHz, 1.0 T) per TEMPO.",

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AU - Tanimoto, Emi

AU - Karasawa, Satoru

AU - Ueki, Shoji

AU - Nitta, Nobuhiro

AU - Aoki, Ichio

AU - Koga, Noboru

PY - 2013/3/21

Y1 - 2013/3/21

N2 - Three lipid-oligonucleotides (ODN) carrying TEMPO were prepared and formed a micelle with a diameter of ca. 10 nm. The double strand ODN, lipid-polyT inDS, incorporating TEMPO near the core of the micelle showed the largest water-proton relaxivity, r1, value of 2.4 (25 MHz, 0.59 T) and 6.8 mM-1 s-1 (42 MHz, 1.0 T) per TEMPO.

AB - Three lipid-oligonucleotides (ODN) carrying TEMPO were prepared and formed a micelle with a diameter of ca. 10 nm. The double strand ODN, lipid-polyT inDS, incorporating TEMPO near the core of the micelle showed the largest water-proton relaxivity, r1, value of 2.4 (25 MHz, 0.59 T) and 6.8 mM-1 s-1 (42 MHz, 1.0 T) per TEMPO.

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JO - RSC Advances

JF - RSC Advances

IS - 11

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Unexpectedly large water-proton relaxivity of TEMPO incorporated into micelle-oligonucleotides

Abstract

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