Understanding the pathophysiology of Alzheimer's disease and mild cognitive impairment: A mini review on fMRI and ERP studies

Takao Yamasaki, Hiroyuki Muranaka, Yumiko Kaseda, Yasuyo Mimori, Shozo Tobimatsu

    Research output: Contribution to journalReview articlepeer-review

    42 Citations (Scopus)

    Abstract

    The prevalence of Alzheimer's disease (AD) is predicted to increase rapidly in the coming decade, highlighting the importance of early detection and intervention in patients with AD and mild cognitive impairment (MCI). Recently, remarkable advances have been made in the application of neuroimaging techniques in investigations of AD and MCI. Among the various neuroimaging techniques, functional magnetic resonance imaging (fMRI) has many potential advantages, noninvasively detecting alterations in brain function that may be present very early in the course of AD and MCI. In this paper, we first review task-related and resting-state fMRI studies on AD and MCI. We then present our recent fMRI studies with additional event-related potential (ERP) experiments during a motion perception task in MCI. Our results indicate that fMRI, especially when combined with ERP recording, can be useful for detecting spatiotemporal functional changes in AD and MCI patients.

    Original languageEnglish
    Article number719056
    JournalNeurology Research International
    Volume2012
    DOIs
    Publication statusPublished - 2012

    All Science Journal Classification (ASJC) codes

    • Neurology
    • Clinical Neurology

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