Two-generation reproductive toxicity study of tributyltin chloride in female rats

Rika Ogata, Minoru Omura, Yohei Shimasaki, Kazuhiko Kubo, Yuji Oshima, Aou Shuji, Naohide Inoue

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78 Citations (Scopus)


A two-generation reproductive toxicity study of the effects of tributyltin chloride (TBTCI) was conducted in female rats using dietary concentrations of 5, 25, and 125 ppm TBTCI. Reproductive outcomes of dams (number and body weight of pups and the percentage of live pups) and the growth of female pups (the day of eye opening and body weight gain) were significantly decreased in the 125 ppm TBTCI group. A delay in vaginal opening and impaired estrous cyclicity were also observed in the 125 ppm TBTCI group. However, an increase in anogenital distance was found in all TBTCI groups on postnatal d 1. A dose-effect relationship was observed in TBTCI-induced changes in anogenital distance. These results indicate that the whole-life exposure to TBTCI affects the sexual development and reproductive function of female rats. In addition, the TBTCI-induced increase in anogenital distance seems to suggest it may exert a masculinizing effect on female neonates. However, the concentrations of TBTCI used in this study are not environmentally relevant.

Original languageEnglish
Pages (from-to)127-144
Number of pages18
JournalJournal of Toxicology and Environmental Health - Part A
Issue number2
Publication statusPublished - May 25 2001

All Science Journal Classification (ASJC) codes

  • Toxicology
  • Health, Toxicology and Mutagenesis


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