TY - JOUR
T1 - Two cases of histiocytic necrotizlng lymphadenitis (kikuchi-fujimoto’s disease) following diffuse large B-cell lymphoma
AU - Yoshino, Tadashi
AU - Mannami, Tomohiko
AU - Ichimura, Koichi
AU - Takenaka, Katsuto
AU - Nose, Soichiro
AU - Yamadori, Ichiro
AU - Akagi, Tadaatsu
N1 - Funding Information:
From the Department of Pathology, Internal Medicine Okayama University Medical School, Okayama, Japan. This work was supported, in part, by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science, Sports, and Culture of Japan. Address correspondence and reprint requests to Tadashi Yo-shino, MD, Department of Pathology, Okayama University Medical School, 2-5-1 Shikata-cho, Okayama, 700-8558, Japan. Copyright © 2000 by W.B. Saunders Company 0046-8177/00/3110-0022$10.00/0 doi:10.1053/hupa.2000.18504
PY - 2000
Y1 - 2000
N2 - Histiocytic necrotizing lymphadenitis (HNL) is often mistaken for malignant lymphoma clinically and is also sometimes difficult to differentiate from lymphoma even histopathologically. In this report, we describe the first 2 reported cases of HNL following non-Hodgkin’s lymphomas. The patients were 27- and 30-year-old women who developed cervical and axillary lymph node swellings, respectively, in the course of remission of diffuse large B-cell lymphoma. The affected lymph nodes showed the typical histology of HNL: irregular-shaped ’necrotic’ foci with histiocytes engulfing apoptotic bodies intermingled with large-sized blastic lymphocytes. These findings mimicked the partial involvement of large-cell lymphoma. However, the blastic cells were almost exclusively T cells, and numerous apoptotic bodies were present, which excluded the possibility of recurrence of diffuse large B-cell lymphoma. Copyright (C) 2000 by W.B. Saunders Company.
AB - Histiocytic necrotizing lymphadenitis (HNL) is often mistaken for malignant lymphoma clinically and is also sometimes difficult to differentiate from lymphoma even histopathologically. In this report, we describe the first 2 reported cases of HNL following non-Hodgkin’s lymphomas. The patients were 27- and 30-year-old women who developed cervical and axillary lymph node swellings, respectively, in the course of remission of diffuse large B-cell lymphoma. The affected lymph nodes showed the typical histology of HNL: irregular-shaped ’necrotic’ foci with histiocytes engulfing apoptotic bodies intermingled with large-sized blastic lymphocytes. These findings mimicked the partial involvement of large-cell lymphoma. However, the blastic cells were almost exclusively T cells, and numerous apoptotic bodies were present, which excluded the possibility of recurrence of diffuse large B-cell lymphoma. Copyright (C) 2000 by W.B. Saunders Company.
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U2 - 10.1053/hupa.2000.18504
DO - 10.1053/hupa.2000.18504
M3 - Article
C2 - 11070128
AN - SCOPUS:0033623493
SN - 0046-8177
VL - 31
SP - 1328
EP - 1331
JO - Human Pathology
JF - Human Pathology
IS - 10
ER -