Two Cases of Angiosarcoma with Persistent Unilateral Eyelid Swelling

Shinzo Sakisaka, Mika Tanabe, Shuhei Imayama, Nahoko Zeze, Kanako Yamana, Hiroshi Yoshikawa, Koh Hei Sonoda

Research output: Contribution to journalArticlepeer-review


Angiosarcoma is a widely known neoplasm with one of the poorest prognoses; however, such cases are rarely observed by the ophthalmologists in clinical practice. The tumor commonly develops on the face and scalp and may cause eyelid swelling. We present 2 such cases. Case 1 was an 82-year-old woman who presented with indulated swelling of the right eyelid that extended to the upper forehead. Biopsy revealed a poorly circumscribed tumor infiltrated throughout the dermis and fat tissue, exhibiting both angiomatous and solid patterns. Immunohistochemistry showed CD31(-) and D2-40/podoplanin(+), suggesting angiosarcoma. The patient had multiple lung metastases and died 14 months later. Case 2 was a 77-year-old man who presented with swelling of the left eyelid, and erythema on the left temporal skin developed ulcerated nodules. Biopsy showed proliferated tumor cells in a sheet form, extensively throughout the dermis. Angiosarcoma was preferred based on immunohistochemistry: CD31(+), CD34(+), and D2-40(-). The patient was treated with electron beam therapy and chemotherapy and died after 13 months. It would be difficult for an ophthalmologist to suspect such a rare neoplasm only from swelling of the eyelids. However, angiosarcoma should be considered if the swelling spreads steadily from a head rash with a nodule or ulcer nearby.

Original languageEnglish
Pages (from-to)16-21
Number of pages6
JournalOcular Oncology and Pathology
Issue number1
Publication statusPublished - Feb 1 2022

All Science Journal Classification (ASJC) codes

  • General Nursing


Dive into the research topics of 'Two Cases of Angiosarcoma with Persistent Unilateral Eyelid Swelling'. Together they form a unique fingerprint.

Cite this