Tumor-derived tenascin-C promotes the epithelial-mesenchymal transition in colorectal cancer cells

Yusuke Takahashi, Genta Sawada, Junji Kurashige, Tae Matsumura, Ryutaro Uchi, Hiroki Ueo, Masahisa Ishibashi, Yuki Takano, Sayuri Akiyoshi, Takeshi Iwaya, Hidetoshi Eguchi, Tomoya Sudo, Keishi Sugimachi, Hirofumi Yamamoto, Yuichiro Doki, Masaki Mori, Koshi Mimori

Research output: Contribution to journalArticlepeer-review

26 Citations (Scopus)


Background: Tenascin-C (TNC) is an extracellular matrix glycoprotein, usually derived from myofibroblasts in the cancer microenvironment. Recently, however, the significance of tumor-derived TNC in initiation of cancer metastasis was disclosed. We investigated the clinical significance of cancer-derived TNC in colorectal cancer (CRC) cases. Materials and Methods: TNC expression in 170 cases of CRC was analyzed by quantitative real-time polymerase chain reaction (PCR). In addition, gene expression arrays using purely-separated cancer tissues of another 86 cases was performed and the functional implications of cancer-specific TNC were investigated. Results: The expression of TNC mRNA was significantly higher in CRC tissues than in the corresponding normal tissues. Cancer cell-specific TNC expression was a significant prognostic factor in CRC cases. Moreover, cancer cell-derived TNC was associated with the epithelial-mesenchymal transition (EMT) signature. Conclusion: Cancer cell-derived TNC promotes cancer invasiveness via EMT regulation, and not cancer tissue TNC but cancer cell-specific TNC is a novel indicator of poor prognosis.

Original languageEnglish
Pages (from-to)1927-1934
Number of pages8
JournalAnticancer research
Issue number5
Publication statusPublished - May 2013

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research


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