Tsukushi controls the hair cycle by regulating TGF-Β1 signaling

Daisuke Niimori, Rie Kawano, Athary Felemban, Kanako Niimori-Kita, Hideaki Tanaka, Hironobu Ihn, Kunimasa Ohta

Research output: Contribution to journalArticlepeer-review

40 Citations (Scopus)


The hair follicle contains stem/progenitor cells that supply progeny for skin development and the hair cycle. Several signaling molecules belonging to the Wnt, BMP, shh, and transforming growth factor Β (TGF-Β) signaling cascades are involved in the normal hair follicle cycle. However, the systemic mechanism of how these humoral factors are controlled remains largely unknown. Previously, we reported that Tsukushi (TSK), a member of the small leucine-rich repeat proteoglycan family, functions extracellularly as a key coordinator of multiple signaling networks. Here, we show that TSK is expressed at the restricted areas of hair follicle during the morphogenesis and the hair cycle. Targeted disruption of the TSK gene causes the hair cycle to be delayed with low levels of TGF-Β1 and phosphorylated Smad2/3 (pSmad2/3) expression. Biochemical analysis indicates that TSK directly binds to TGF-Β1. Our data suggest that TSK controls the hair cycle by regulating TGF-Β1 signaling.

Original languageEnglish
Pages (from-to)81-87
Number of pages7
JournalDevelopmental Biology
Issue number1
Publication statusPublished - Dec 1 2012
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Developmental Biology
  • Cell Biology


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