Triterpenoid saponins from Hydrocotyle bonariensis Lam

Turibio Kuiate Tabopda, Anne Claire Mitaine-Offer, Tomofumi Miyamoto, Chiaki Tanaka, Jean Franois Mirjolet, Olivier Duchamp, Bonaventure Tchaleu Ngadjui, Marie Aleth Lacaille-Dubois

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)


Phytochemical investigation of the under-ground parts of Hydrocotyle bonariensis led to the isolation of five oleanane-type triterpenoid saponins, 3-O-{β-d-glucopyranosyl-(1 → 2)-[α-l-arabinopyranosyl-(1 → 3)]-β-d-glucuronopyranosyl}-21-O-(2-methylbutyroyl)-22-O-acetyl-R 1-barrigenol, 3-O-{β-d-glucopyranosyl-(1 → 2)-[α-l-arabinopyranosyl-(1 → 3)]-β-d-glucuronopyranosyl}-21-O- (2-methylbutyroyl)-28-O-acetyl-R 1-barrigenol, 3-O-{β-d- glucopyranosyl-(1 → 2)-[α-l-arabinopyranosyl-(1 → 3)]-β-d-glucuronopyranosyl}-21-O-acetyl-R 1-barrigenol, 3-O-{β-d-glucopyranosyl-(1 → 2)-[α-l-arabinopyranosyl-(1 → 3)]-β-d-glucuronopyranosyl}-R 1-barrigenol, and 3-O-{β-d-glucopyranosyl-(1 → 2)-[α-l-arabinopyranosyl-(1 → 3)]-β-d-glucuronopyranosyl}-22-O-(2-methylbutyroyl)-A 1- barrigenol, together with the known saniculoside-R1. Their structures were established by 2D NMR techniques and mass spectrometry. Six compounds were evaluated against two human colon cancer cell lines, HCT 116 and HT-29. Two compounds showed weak cytotoxicity with IC 50 24.1 and 24.0, 83.0 and 83.6 μM against HT-29 and HCT 116, respectively.

Original languageEnglish
Pages (from-to)142-147
Number of pages6
Publication statusPublished - Jan 2012

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Plant Science
  • Horticulture


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