Triterpene saponins from cyclamen trocopteranthum

Ghezala Mihci-Gaidi; Suheyla Ozbey; Ilkay Orhan; Bilge Sener; Tomofumi Miyamoto; Jean François Mirjolet; Olivier Duchamp; Anne Claire Mitaine-Offer; Marie Aleth Lacaille-Dubois

doi:10.1055/s-0029-1240727

Triterpene saponins from cyclamen trocopteranthum

Ghezala Mihci-Gaidi, Suheyla Ozbey, Ilkay Orhan, Bilge Sener, Tomofumi Miyamoto, Jean François Mirjolet, Olivier Duchamp, Anne Claire Mitaine-Offer, Marie Aleth Lacaille-Dubois

Pharmaceutical Health Care and Sciences

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

Two new triterpene saponins (12) together with three known saponins, deglucocyclamin I (3), cyclamin (4), and mirabilin (5), were isolated from the tubers of Cyclamen trocopteranthum. They were elucidated as 3-O-{4-O-[3- hydroxyl-3-methylglutaryl] - D-xylopyranosyl-(12) - D-glucopyranosyl-(14)-[-D- glucopyranosyl-(12)] - L-arabinopyranosyl}-16-hydroxy-13,28-epoxy-oleanan-30-al (1) and 3-O-{4-O-[3-hydroxyl-3-methylglutaryl] - D-xylopyranosyl-(12)-[-D- glucopyranosyl-(16)] - D-glucopyranosyl-(14)-[-D-glucopyranosyl-(12)] - L-arabinopyranosyl}-16-hydroxy-20,30-lactone-olean-12-ene (2). Their structures were characterized mainly by a combination of 1D- and 2DNMR techniques ( ¹H-¹H COSY, TOCSY, NOESY, HSQC, and HMBC) and mass spectroscopy. Saponins 1, 3, and 4 showed a weak cytotoxic activity when tested against HT-29 and HCT 116 tumor colon cancer cells.

Original language	English
Pages (from-to)	818-821
Number of pages	4
Journal	Planta medica
Volume	76
Issue number	8
DOIs	https://doi.org/10.1055/s-0029-1240727
Publication status	Published - Jun 4 2010

All Science Journal Classification (ASJC) codes

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Triterpene saponins from cyclamen trocopteranthum",

abstract = "Two new triterpene saponins (12) together with three known saponins, deglucocyclamin I (3), cyclamin (4), and mirabilin (5), were isolated from the tubers of Cyclamen trocopteranthum. They were elucidated as 3-O-{4-O-[3- hydroxyl-3-methylglutaryl] - D-xylopyranosyl-(12) - D-glucopyranosyl-(14)-[-D- glucopyranosyl-(12)] - L-arabinopyranosyl}-16-hydroxy-13,28-epoxy-oleanan-30-al (1) and 3-O-{4-O-[3-hydroxyl-3-methylglutaryl] - D-xylopyranosyl-(12)-[-D- glucopyranosyl-(16)] - D-glucopyranosyl-(14)-[-D-glucopyranosyl-(12)] - L-arabinopyranosyl}-16-hydroxy-20,30-lactone-olean-12-ene (2). Their structures were characterized mainly by a combination of 1D- and 2DNMR techniques ( 1H-1H COSY, TOCSY, NOESY, HSQC, and HMBC) and mass spectroscopy. Saponins 1, 3, and 4 showed a weak cytotoxic activity when tested against HT-29 and HCT 116 tumor colon cancer cells.",

author = "Ghezala Mihci-Gaidi and Suheyla Ozbey and Ilkay Orhan and Bilge Sener and Tomofumi Miyamoto and Mirjolet, {Jean Fran{\c c}ois} and Olivier Duchamp and Mitaine-Offer, {Anne Claire} and Lacaille-Dubois, {Marie Aleth}",

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T1 - Triterpene saponins from cyclamen trocopteranthum

AU - Mihci-Gaidi, Ghezala

AU - Ozbey, Suheyla

AU - Orhan, Ilkay

AU - Sener, Bilge

AU - Miyamoto, Tomofumi

AU - Mirjolet, Jean François

AU - Duchamp, Olivier

AU - Mitaine-Offer, Anne Claire

AU - Lacaille-Dubois, Marie Aleth

PY - 2010/6/4

Y1 - 2010/6/4

N2 - Two new triterpene saponins (12) together with three known saponins, deglucocyclamin I (3), cyclamin (4), and mirabilin (5), were isolated from the tubers of Cyclamen trocopteranthum. They were elucidated as 3-O-{4-O-[3- hydroxyl-3-methylglutaryl] - D-xylopyranosyl-(12) - D-glucopyranosyl-(14)-[-D- glucopyranosyl-(12)] - L-arabinopyranosyl}-16-hydroxy-13,28-epoxy-oleanan-30-al (1) and 3-O-{4-O-[3-hydroxyl-3-methylglutaryl] - D-xylopyranosyl-(12)-[-D- glucopyranosyl-(16)] - D-glucopyranosyl-(14)-[-D-glucopyranosyl-(12)] - L-arabinopyranosyl}-16-hydroxy-20,30-lactone-olean-12-ene (2). Their structures were characterized mainly by a combination of 1D- and 2DNMR techniques ( 1H-1H COSY, TOCSY, NOESY, HSQC, and HMBC) and mass spectroscopy. Saponins 1, 3, and 4 showed a weak cytotoxic activity when tested against HT-29 and HCT 116 tumor colon cancer cells.

AB - Two new triterpene saponins (12) together with three known saponins, deglucocyclamin I (3), cyclamin (4), and mirabilin (5), were isolated from the tubers of Cyclamen trocopteranthum. They were elucidated as 3-O-{4-O-[3- hydroxyl-3-methylglutaryl] - D-xylopyranosyl-(12) - D-glucopyranosyl-(14)-[-D- glucopyranosyl-(12)] - L-arabinopyranosyl}-16-hydroxy-13,28-epoxy-oleanan-30-al (1) and 3-O-{4-O-[3-hydroxyl-3-methylglutaryl] - D-xylopyranosyl-(12)-[-D- glucopyranosyl-(16)] - D-glucopyranosyl-(14)-[-D-glucopyranosyl-(12)] - L-arabinopyranosyl}-16-hydroxy-20,30-lactone-olean-12-ene (2). Their structures were characterized mainly by a combination of 1D- and 2DNMR techniques ( 1H-1H COSY, TOCSY, NOESY, HSQC, and HMBC) and mass spectroscopy. Saponins 1, 3, and 4 showed a weak cytotoxic activity when tested against HT-29 and HCT 116 tumor colon cancer cells.

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Triterpene saponins from cyclamen trocopteranthum

Abstract

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