Triplet Dynamic Nuclear Polarization of Guest Molecules through Induced Fit in a Flexible Metal–Organic Framework**

Saiya Fujiwara, Naoto Matsumoto, Koki Nishimura, Nobuo Kimizuka, Kenichiro Tateishi, Tomohiro Uesaka, Nobuhiro Yanai

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

Dynamic nuclear polarization utilizing photoexcited triplet electrons (triplet-DNP) has great potential for room-temperature hyperpolarization of nuclear spins. However, the polarization transfer to molecules of interest remains a challenge due to the fast spin relaxation and weak interaction with target molecules at room temperature in conventional host materials. Here, we demonstrate the first example of DNP of guest molecules in a porous material at around room temperature by utilizing the induced-fit-type structural transformation of a crystalline yet flexible metal–organic framework (MOF). In contrast to the usual hosts, 1H spin-lattice relaxation time becomes longer by accommodating a pharmaceutical model target 5-fluorouracil as the flexible MOF changes its structure upon guest accommodation to maximize the host–guest interactions. Combined with triplet-DNP and cross-polarization (CP), this system realizes an enhanced 19F NMR signal of guest target molecules.

Original languageEnglish
Article numbere202115792
JournalAngewandte Chemie - International Edition
Volume61
Issue number9
DOIs
Publication statusPublished - Feb 21 2022

All Science Journal Classification (ASJC) codes

  • Catalysis
  • General Chemistry

Fingerprint

Dive into the research topics of 'Triplet Dynamic Nuclear Polarization of Guest Molecules through Induced Fit in a Flexible Metal–Organic Framework**'. Together they form a unique fingerprint.

Cite this