TY - JOUR
T1 - Triethylammonium acetate ionic liquid assisted one-pot synthesis of dihydropyrimidinones and evaluation of their antioxidant and antibacterial activities
AU - Attri, Pankaj
AU - Bhatia, Rohit
AU - Gaur, Jitender
AU - Arora, Bharti
AU - Gupta, Anjali
AU - Kumar, Naresh
AU - Choi, Eun Ha
N1 - Funding Information:
We gratefully acknowledge SRC program of National Research Foundation of Korea (NRF) Grant funded by the Korean Government (MEST) (No. 20100029418 ) and in part by Kwangwoon University 2014. J.G. is thankful to DST, Govt. of India, for providing financial support under the India-UK joint initiative project entitled “Advancing the efficiency and production potential of excitonic solar cells (APEX)”.
Publisher Copyright:
© 2014 King Saud University
PY - 2017/2/1
Y1 - 2017/2/1
N2 - A mild and efficient catalytic method has been developed to synthesize 3,4-dihydropyrimidinones in high yield by one-pot three component Biginelli condensation in the presence of triethylammonium acetate (TEAA) which acts as catalyst/reaction medium. Further, we have studied the antioxidant and antibacterial activities of these synthesized 3,4-dihydropyrimidinones. All the synthesized compounds reveal the significant antioxidant properties, these properties have been studied using 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging and cupric reducing antioxidant capacity (CUPRAC) assays. In addition, to this, these compounds also show the good antibacterial activity against four human pathogenic bacteria.
AB - A mild and efficient catalytic method has been developed to synthesize 3,4-dihydropyrimidinones in high yield by one-pot three component Biginelli condensation in the presence of triethylammonium acetate (TEAA) which acts as catalyst/reaction medium. Further, we have studied the antioxidant and antibacterial activities of these synthesized 3,4-dihydropyrimidinones. All the synthesized compounds reveal the significant antioxidant properties, these properties have been studied using 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging and cupric reducing antioxidant capacity (CUPRAC) assays. In addition, to this, these compounds also show the good antibacterial activity against four human pathogenic bacteria.
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U2 - 10.1016/j.arabjc.2014.05.007
DO - 10.1016/j.arabjc.2014.05.007
M3 - Article
AN - SCOPUS:84902023350
SN - 1878-5352
VL - 10
SP - 206
EP - 214
JO - Arabian Journal of Chemistry
JF - Arabian Journal of Chemistry
IS - 2
ER -