Treatment of squamous cell carcinoma of the esophagus synchronously associated with head and neck cancer

Masaru Morita, Akinori Egashira, Yu Nakaji, Masaki Kagawa, Masahiko Sugiyama, Daisuke Yoshida, Mitsuhiko Ota, Masahiko Ikebe, Muneyuki Masuda, Yojiro Inoue, Naonobu Kunitake, Yasushi Toh

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


Background/Aim: The aim of this study was to clarify the treatment strategy for synchronous squamous cell carcinoma of the esophagus (ESCC) and head and neck cancer (HNC). Patients and Methods: Treatment outcomes of 91 patients with synchronous ESCC and HNC were evaluated. Thirty-eight patients received simultaneous definitive chemoradiotherapy (CRT) and 15 patients underwent simultaneous resection. Results: Among the patients who received simultaneous CRT, adverse events (grade 3-5) were recognized in 14 patients (40%), including one case of death due to aspiration pneumonia. Complete response was observed in 22 patients with ESCC (58%) and 19 patients with HNC (50%). The five-year survival rate was 44%. There were no in-hospital deaths after simultaneous resection; however, postoperative complications were recognized in 4 patients. The five-year OS was 70%. Conclusion: The treatment of synchronous ESCC and HNC must be decided by adopting a strategy that is appropriate for each case. Both simultaneous CRT and simultaneous resection are feasible and effective treatment options.

Original languageEnglish
Pages (from-to)909-916
Number of pages8
JournalIn Vivo
Issue number5
Publication statusPublished - Sept 1 2017
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology


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