Treatment of advanced gastric cancer with 5-fluorouracil and cisplatin in combination with dipyridamole

Shunji Kohnoe, Yoshihiko Maehara, Ikuo Takahashi, Yasunori Emi, Hideo Baba, Keizo Sugimachi

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15 Citations (Scopus)


We investigated the efficacy of combination chemotherapy using 5- fluorouracil (5-FU), cisplatin (CDDP), and dipyridamole (DP), which is based on the concept of double biochemical modulation. Twenty-eight patients with advanced gastric cancer were treated with the simultaneous continuous intravenous (i.v.) infusion of 5-FU (800 mg/m2/day) and DP (4 mg/kg/day), and i.v. infusion of CDDP (20 mg/m2/day) for 5 days. The cycles were repeated every 4 weeks. Twelve patients (43%) had a partial response (PR), while stable disease (NC) occurred in 13 patients (46%), and progression (PD) in 3 patients (11%). An improved performance status was observed in 20 patients (71%). The carcinoembryonic antigen (CEA) level was markedly decreased in 75% of the CEA-positive patients. Toxicity was acceptable. The mean steady state plasma concentration of total DP was 6.4±0.5 μM, which thus seemed adequate to potentiate the cytotoxicity of 5-FU. The treatment regimen described herein thus appears to be effective, safe and well tolerated by patients with advanced gastric cancer.

Original languageEnglish
Pages (from-to)1203-1206
Number of pages4
JournalInternational journal of oncology
Issue number6
Publication statusPublished - Dec 1998

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research


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