Treatment for infectious due to carbapenem-resistant Enterobacteriaceae

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In Japan, criteria for carbapenem-resistant Enterobacteriaceae(CRE) are established based on MIC values, but are not the same as European or US ones. In addition, CRE is not synonymous with carbapenemase-producing Enterobacteriaceae(CPE). In case of carbapenem-resistant strains, CPE is significant for infection control and treatment. It is important to know the type of CPE, for example, the KPC type, IMP type, VIM type, NDM type etc. The IMP type is the most common in Japan, but worldwide the KPC and NDM types are most problematic regarding the treatment because of their high resistance. Colistin, tigecycline, fosfomycin and aminoglycosides are therapeutic agents for CPE infection. It is recommended to use Colistin or tigecycline as combination agents and not as a single agent in the treatment. Carbapenems are also the candidates for therapeutic agents in combination with other agents in case the strain is not highly resistant against carbapenems (MIC> 8 μg/mL). As new antimicrobial drugs for CPE, new beta lactam beta lactamase inhibitors, new aminoglycoside derivatives, tetracycline-based antibiotics and siderophore antibiotics are under development. Most importantly, we should re-realize that therapeutic strategies for infectious diseases are not different even if the causative organisms are drug resistant. We should not try to treat a patient colonized with CPE, we should perform surgical drainage when possible, and so on.

Original languageEnglish
Pages (from-to)742-749
Number of pages8
JournalJapanese Journal of Chemotherapy
Issue number5
Publication statusPublished - Sept 2016

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)


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