Transplantation of neural stem cells with valproate for spinal cord injury

Masahiko Abematsu, Kinichi Nakashima

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)


The regenerative capacity of an injured spinal cord is limited, and once paralysis occurs, it is difficult to improve the situation. We have developed a treatment method called the HINT method (HDAC Inhibitor and Neural stem cell Transplantation) that improves hind limb motor functionality in mice with severe spinal cord injuries by using a combination of antiepileptic drugs and neural stem cells. This chapter will introduce you to the new neural damage reconstruction mechanism employed in the HINT method.

Original languageEnglish
Title of host publicationNeuroprotection and Regeneration of the Spinal Cord
PublisherSpringer Japan
Number of pages7
ISBN (Electronic)9784431545026
ISBN (Print)4431545018, 9784431545019
Publication statusPublished - Nov 1 2014

All Science Journal Classification (ASJC) codes

  • Medicine(all)


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