TY - JOUR
T1 - Transition of serum cytokines following pancreaticoduodenectomy
T2 - A subsidiary study of JAPAN-PD
AU - Maeda, Hiromichi
AU - Okada, Ken Ichi
AU - Fujii, Tsutomu
AU - Oba, Mari S.
AU - Kawai, Manabu
AU - Hirono, Seiko
AU - Kodera, Yasuhiro
AU - Sho, Masayuki
AU - Akahori, Takahiro
AU - Shimizu, Yasuhiro
AU - Ambo, Yoshiyasu
AU - Kondo, Naru
AU - Murakami, Yoshiaki
AU - Ohuchida, Jiro
AU - Eguchi, Hidetoshi
AU - Nagano, Hiroaki
AU - Sakamoto, Junichi
AU - Yamaue, Hiroki
N1 - Publisher Copyright:
© 2018, Spandidos Publications. All rights reserved.
PY - 2018/11
Y1 - 2018/11
N2 - Our previous study aimed to examine the effect of TJ-100, a widely used herbal medicine, on intestinal function following pancreaticoduodenectomy (PD) in a multicenter, randomized, double-blinded, placebo-controlled manner (JAPAN-PD study). This concomitant study investigated the effect of TJ-100 on serum cytokine levels in patients who underwent PD. Due to the fact that several clinical variables can affect the absolute values of baseline serum cytokine levels, the ratios of the cytokine levels on postoperative day (POD)3 to those on POD1 were also used for analysis. The present study enrolled 180/224 randomized patients, of whom 91 received TJ-100 and 89 received placebo. As the main findings of the analysis, Wilcoxon signed-rank test revealed no significant difference in the levels of serum cytokines between the groups; however, patients in the TJ-100 group without severe inflammatory complications exhibited significantly higher ratios of interleukin (IL)-4 (n=123), IL-9 (n=72), IL-10 (n=97), PDGF-BB (n=143) and tumor necrosis factor-α (n=135), compared with patients in the Placebo Group (P<0.05). According to the results of the present study, TJ-100 has an effect on the change in serum cytokine levels from POD1 to POD3 following PD. However, the role of different transition pattern of cytokines in postoperative recovery following PD has to be investigated by further mechanical studies focusing on these extracted cytokines (ClinicalTrials.gov; no. NCT01607307; May 30, 2012).
AB - Our previous study aimed to examine the effect of TJ-100, a widely used herbal medicine, on intestinal function following pancreaticoduodenectomy (PD) in a multicenter, randomized, double-blinded, placebo-controlled manner (JAPAN-PD study). This concomitant study investigated the effect of TJ-100 on serum cytokine levels in patients who underwent PD. Due to the fact that several clinical variables can affect the absolute values of baseline serum cytokine levels, the ratios of the cytokine levels on postoperative day (POD)3 to those on POD1 were also used for analysis. The present study enrolled 180/224 randomized patients, of whom 91 received TJ-100 and 89 received placebo. As the main findings of the analysis, Wilcoxon signed-rank test revealed no significant difference in the levels of serum cytokines between the groups; however, patients in the TJ-100 group without severe inflammatory complications exhibited significantly higher ratios of interleukin (IL)-4 (n=123), IL-9 (n=72), IL-10 (n=97), PDGF-BB (n=143) and tumor necrosis factor-α (n=135), compared with patients in the Placebo Group (P<0.05). According to the results of the present study, TJ-100 has an effect on the change in serum cytokine levels from POD1 to POD3 following PD. However, the role of different transition pattern of cytokines in postoperative recovery following PD has to be investigated by further mechanical studies focusing on these extracted cytokines (ClinicalTrials.gov; no. NCT01607307; May 30, 2012).
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U2 - 10.3892/ol.2018.9422
DO - 10.3892/ol.2018.9422
M3 - Article
AN - SCOPUS:85054307538
SN - 1792-1074
VL - 16
SP - 6847
EP - 6853
JO - Oncology Letters
JF - Oncology Letters
IS - 5
ER -
