TY - JOUR
T1 - Transient Elastography for the prediction of oxaliplatin-associated liver injury in colon cancer patients
T2 - A preliminary analysis
AU - Oki, Eiji
AU - Kakeji, Yoshihiro
AU - Taketomi, Akinobu
AU - Yamashita, Yoichi
AU - Ohgaki, Kippei
AU - Harada, Noboru
AU - Iguchi, Tomohiro
AU - Shibahara, Kotaro
AU - Sadanaga, Noriaki
AU - Morita, Masaru
AU - Maehara, Yoshihiko
PY - 2008/3
Y1 - 2008/3
N2 - Objective: The prognosis of advanced colon cancer has improved significantly over the last decade since new chemotherapy regimens including oxaliplatin have been developed. However, oxaliplatin-induced liver injury and characterized hepatic hemostatic status can occur after chemotherapy. The assessment of this type of liver injury is often difficult. Methods: Elastography (Fibroscan™) was used to evaluate liver injury in five cases before and after 5-FU, leucovorin, and oxaliplatin combination (FOLFOX) treatment. Results: A clear change was observed in the stiffness of liver after chemotherapy within 48 h, and the hepatic stiffness was normalized in most cases after 2 weeks. Among the five patients, one patient showed aberrant elevation after a FOLFOX treatment, and the patient showed liver injury pathologically. Conclusion: Elastography is a good tool for evaluating hepatic injury after FOLFOX treatment.
AB - Objective: The prognosis of advanced colon cancer has improved significantly over the last decade since new chemotherapy regimens including oxaliplatin have been developed. However, oxaliplatin-induced liver injury and characterized hepatic hemostatic status can occur after chemotherapy. The assessment of this type of liver injury is often difficult. Methods: Elastography (Fibroscan™) was used to evaluate liver injury in five cases before and after 5-FU, leucovorin, and oxaliplatin combination (FOLFOX) treatment. Results: A clear change was observed in the stiffness of liver after chemotherapy within 48 h, and the hepatic stiffness was normalized in most cases after 2 weeks. Among the five patients, one patient showed aberrant elevation after a FOLFOX treatment, and the patient showed liver injury pathologically. Conclusion: Elastography is a good tool for evaluating hepatic injury after FOLFOX treatment.
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U2 - 10.1007/s12029-009-9063-1
DO - 10.1007/s12029-009-9063-1
M3 - Article
C2 - 19377909
AN - SCOPUS:69849108631
SN - 1941-6628
VL - 39
SP - 82
EP - 85
JO - Journal of Gastrointestinal Cancer
JF - Journal of Gastrointestinal Cancer
IS - 1-4
ER -
