TY - JOUR
T1 - Transdifferentiation of human somatic cells by ribosome
AU - Ito, Naofumi
AU - Anam, Mohammad Badrul
AU - Ahmad, Shah Adil Ishtiyaq
AU - Ohta, Kunimasa
N1 - Funding Information:
We are grateful to Dr. Harukazu Nakamura for critical reading of the manuscript. We also thank Megumi Takiguchi, Kazumi Urata and Mitsue Kumamaru for their helpful assistance. This work was supported by grants from KAKENHI (25650082, 16K18553), Kumamoto University Advanced Research Project “Stem Cell-Based Tissue Regeneration Research and Education Unit, Kumamoto University Program for Leading Graduate Schools “HIGOprogram”, Japan Agency for Medical Research and Development,” Astellas Foundation for Research on Metabolic Disorders, the Mitsubishi Foundation, the Yamada Science Foundation, and Institute for Fermentation Osaka.
Funding Information:
KAKENHI, Grant/Award Number: 25650082 and 16K18553; Kumamoto University Advanced Research Project “Stem Cell-Based Tissue Regeneration Research and Education Unit; Kumamoto University Program for Leading Graduate Schools “HIGOprogram”; Japan Agency for Medical Research and Development; Astellas Foundation for Research on Metabolic Disorders; Mitsubishi Foundation; Yamada Science Foundation; Institute for Fermentation Osaka
Publisher Copyright:
© 2018 Japanese Society of Developmental Biologists
PY - 2018/6
Y1 - 2018/6
N2 - Ribosomes are intracellular organelles ubiquitous in all organisms, which translate information from mRNAs to synthesize proteins. They are complex macromolecules composed of dozens of proteins and ribosomal RNAs. Other than translation, some ribosomal proteins also have side-jobs called “Moonlighting” function. The majority of these moonlighting functions influence cancer progression, early development and differentiation. Recently, we discovered that ribosome is involved in the regulation of cellular transdifferentiation of human dermal fibroblasts (HDFs). In vitro incorporation of ribosomes into HDFs arrests cell proliferation and induces the formation of cell clusters, that differentiate into three germ layer derived cells upon induction by differentiation mediums. The discovery of ribosome induced transdifferentiation, that is not based on genetic modification, find new possibilities for the treatment of cancer and congenital diseases, as well as to understand early development and cellular lineage differentiation.
AB - Ribosomes are intracellular organelles ubiquitous in all organisms, which translate information from mRNAs to synthesize proteins. They are complex macromolecules composed of dozens of proteins and ribosomal RNAs. Other than translation, some ribosomal proteins also have side-jobs called “Moonlighting” function. The majority of these moonlighting functions influence cancer progression, early development and differentiation. Recently, we discovered that ribosome is involved in the regulation of cellular transdifferentiation of human dermal fibroblasts (HDFs). In vitro incorporation of ribosomes into HDFs arrests cell proliferation and induces the formation of cell clusters, that differentiate into three germ layer derived cells upon induction by differentiation mediums. The discovery of ribosome induced transdifferentiation, that is not based on genetic modification, find new possibilities for the treatment of cancer and congenital diseases, as well as to understand early development and cellular lineage differentiation.
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U2 - 10.1111/dgd.12538
DO - 10.1111/dgd.12538
M3 - Review article
C2 - 29845598
AN - SCOPUS:85048320552
SN - 0012-1592
VL - 60
SP - 241
EP - 247
JO - Development Growth and Differentiation
JF - Development Growth and Differentiation
IS - 5
ER -
