Transcription factors and drug resistance

Kimitoshi Kohno, Takeshi Uchiumi, Ichiro Niina, Tetsuro Wakasugi, Tomonori Igarashi, Yasutomo Momii, Takeshi Yoshida, Ken Ichi Matsuo, Naoya Miyamoto, Hiroto Izumi

Research output: Contribution to journalArticlepeer-review

72 Citations (Scopus)


Intrinsic or acquired resistance to anticancer agents is a major obstacle to the success of chemotherapy. Anticancer agents are known to modulate signal transduction pathways and alter expression of genes that play an important role in drug resistance. Emerging evidence suggests that the complexity of genomic response against anticancer agents arise from elaborate gene expression by multiple transcription factors. Here, we briefly describe the development of solid tumours and the appearance of drug-resistant cells. We also review what is known of the transcription factors that are involved in resistance to drugs, particularly cisplatin.

Original languageEnglish
Pages (from-to)2577-2586
Number of pages10
JournalEuropean Journal of Cancer
Issue number16
Publication statusPublished - Nov 2005
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research


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