Trans-omics Impact of Thymoproteasome in Cortical Thymic Epithelial Cells

Izumi Ohigashi, Yu Tanaka, Kenta Kondo, Sayumi Fujimori, Hiroyuki Kondo, Amy C. Palin, Victoria Hoffmann, Mina Kozai, Yosuke Matsushita, Shinsuke Uda, Ryo Motosugi, Jun Hamazaki, Hiroyuki Kubota, Shigeo Murata, Keiji Tanaka, Toyomasa Katagiri, Hidetaka Kosako, Yousuke Takahama

    Research output: Contribution to journalArticlepeer-review

    26 Citations (Scopus)

    Abstract

    Ohigashi et al. show that the use of cyclin D1-transgenic mice allows quantitative proteomic analysis of cortical and medullary thymic epithelial cells (TECs). Results provide a trans-omics platform for further exploration of TEC biology and reveal the specific impact of the thymoproteasome on proteasome subunit composition in cortical TECs.

    Original languageEnglish
    Pages (from-to)2901-2916.e6
    JournalCell Reports
    Volume29
    Issue number9
    DOIs
    Publication statusPublished - Nov 26 2019

    All Science Journal Classification (ASJC) codes

    • General Biochemistry,Genetics and Molecular Biology

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