Toxicity of single-walled carbon nanohorns

Jin Miyawaki, Masako Yudasaka, Takeshi Azami, Yoshimi Kubo, Sumio Iijima

Research output: Contribution to journalArticlepeer-review

230 Citations (Scopus)


We extensively investigated in vitro and in vivo the toxicities of as-grown single-walled carbon nanohorns (SWNHs), a tubular nanocarbon containing no metal impurity. The SWNHs were found to be a nonirritant and a nondermal sensitizer through skin primary and conjunctival irritation tests and skin sensitization test. Negative mutagenic and clastogenic potentials suggest that SWNHs are not carcinogenic. The acute peroral toxicity of SWNHs was found to be quite low - the lethal dosage for rats was more than 2000 mg/kg of body weight. Intratracheal instillation tests revealed that SWNHs rarely damaged rat lung tissue for a 90-day test period, although black pigmentation due to accumulated nanohorns was observed. While further toxicological assessments, including chronic (repeated dose), reproductive, and developmental toxicity studies, are still needed, yet the present results strongly suggest that as-grown SWNHs have low acute toxicities.

Original languageEnglish
Pages (from-to)213-226
Number of pages14
JournalACS nano
Issue number2
Publication statusPublished - Feb 2008

All Science Journal Classification (ASJC) codes

  • General Materials Science
  • General Engineering
  • General Physics and Astronomy


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