Toxic epidermal necrolysis in a child 6 months post-hematopoietic stem cell transplantation

Utako Oba; Hiroshi Yamada; So Ichi Suenobu; Yusuke Nakamura; Akiko Ito; Yutaka Hatano; Nobuyoshi Itonaga; Kouichi Ohshima; Yuhki Koga; Shouichi Ohga; Kenji Ihara

doi:10.1111/petr.12931

Toxic epidermal necrolysis in a child 6 months post-hematopoietic stem cell transplantation

Utako Oba, Hiroshi Yamada, So Ichi Suenobu, Yusuke Nakamura, Akiko Ito, Yutaka Hatano, Nobuyoshi Itonaga, Kouichi Ohshima, Yuhki Koga, Shouichi Ohga, Kenji Ihara

Faculty of Medical Sciences

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

TEN is a rare and critical disease mostly caused by drugs. It is mediated by activated CD8+ T cells that cause keratinocyte apoptosis with the assistance of cytokines/chemokines. We herein report a pediatric case of TEN after allogeneic HSCT with precursor B-cell acute lymphoblastic leukemia (pre-B-ALL) in second complete remission. Although we did not evaluate the T-cell subpopulation in blood or skin lesion of the patient, an imbalanced immune reconstitution after HSCT might additively contribute to the development of TEN.

Original language	English
Article number	e12931
Journal	Pediatric Transplantation
Volume	21
Issue number	5
DOIs	https://doi.org/10.1111/petr.12931
Publication status	Published - Aug 2017

All Science Journal Classification (ASJC) codes

Pediatrics, Perinatology, and Child Health
Transplantation

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10.1111/petr.12931

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title = "Toxic epidermal necrolysis in a child 6 months post-hematopoietic stem cell transplantation",

abstract = "TEN is a rare and critical disease mostly caused by drugs. It is mediated by activated CD8+ T cells that cause keratinocyte apoptosis with the assistance of cytokines/chemokines. We herein report a pediatric case of TEN after allogeneic HSCT with precursor B-cell acute lymphoblastic leukemia (pre-B-ALL) in second complete remission. Although we did not evaluate the T-cell subpopulation in blood or skin lesion of the patient, an imbalanced immune reconstitution after HSCT might additively contribute to the development of TEN.",

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language = "English",

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T1 - Toxic epidermal necrolysis in a child 6 months post-hematopoietic stem cell transplantation

AU - Oba, Utako

AU - Yamada, Hiroshi

AU - Suenobu, So Ichi

AU - Nakamura, Yusuke

AU - Ito, Akiko

AU - Hatano, Yutaka

AU - Itonaga, Nobuyoshi

AU - Ohshima, Kouichi

AU - Koga, Yuhki

AU - Ohga, Shouichi

AU - Ihara, Kenji

PY - 2017/8

Y1 - 2017/8

N2 - TEN is a rare and critical disease mostly caused by drugs. It is mediated by activated CD8+ T cells that cause keratinocyte apoptosis with the assistance of cytokines/chemokines. We herein report a pediatric case of TEN after allogeneic HSCT with precursor B-cell acute lymphoblastic leukemia (pre-B-ALL) in second complete remission. Although we did not evaluate the T-cell subpopulation in blood or skin lesion of the patient, an imbalanced immune reconstitution after HSCT might additively contribute to the development of TEN.

AB - TEN is a rare and critical disease mostly caused by drugs. It is mediated by activated CD8+ T cells that cause keratinocyte apoptosis with the assistance of cytokines/chemokines. We herein report a pediatric case of TEN after allogeneic HSCT with precursor B-cell acute lymphoblastic leukemia (pre-B-ALL) in second complete remission. Although we did not evaluate the T-cell subpopulation in blood or skin lesion of the patient, an imbalanced immune reconstitution after HSCT might additively contribute to the development of TEN.

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M3 - Article

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JO - Pediatric Transplantation

JF - Pediatric Transplantation

IS - 5

M1 - e12931

ER -

Toxic epidermal necrolysis in a child 6 months post-hematopoietic stem cell transplantation

Abstract

All Science Journal Classification (ASJC) codes

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