Total synthesis of the proposed structure of brevenal

Haruhiko Fuwa, Makoto Ebine, Makoto Sasaki

Research output: Contribution to journalArticlepeer-review

60 Citations (Scopus)


Total synthesis of the proposed structure of brevenal, a natural marine polycyclic ether product, has been accomplished. The synthesis features (i) convergent synthesis of the pentacyclic polyether skeleton using our developed Suzuki-Miyaura coupling strategy and (ii) construction of the multi-substituted dienal side chain by CuTC-mediated Stille reaction. Comparison of the NMR data of the synthetic compound with those reported for the natural product revealed that the proposed structure of brevenal needs to be revised.

Original languageEnglish
Pages (from-to)9648-9650
Number of pages3
JournalJournal of the American Chemical Society
Issue number30
Publication statusPublished - Aug 2 2006
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Catalysis
  • General Chemistry
  • Biochemistry
  • Colloid and Surface Chemistry


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