Total synthesis of (+)-bongkrekic acid

Mitsuru Shindo; Tomoyuki Sugioka; Yuko Umaba; Kozo Shishido

doi:10.1016/j.tetlet.2004.09.162

Total synthesis of (+)-bongkrekic acid

Mitsuru Shindo, Tomoyuki Sugioka, Yuko Umaba, Kozo Shishido

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Abstract

Total synthesis of bongkrekic acid, an important apoptosis inhibitor, has been accomplished. The strategy includes inexpensive starting materials, asymmetric alkylation, anionic allyl coupling and oxidative manipulations. This process would provide a sufficient amount of bongkrekic acid and its analogues.

Original language	English
Pages (from-to)	8863-8866
Number of pages	4
Journal	Tetrahedron Letters
Volume	45
Issue number	48
DOIs	https://doi.org/10.1016/j.tetlet.2004.09.162
Publication status	Published - Nov 22 2004
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/j.tetlet.2004.09.162

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title = "Total synthesis of (+)-bongkrekic acid",

abstract = "Total synthesis of bongkrekic acid, an important apoptosis inhibitor, has been accomplished. The strategy includes inexpensive starting materials, asymmetric alkylation, anionic allyl coupling and oxidative manipulations. This process would provide a sufficient amount of bongkrekic acid and its analogues.",

author = "Mitsuru Shindo and Tomoyuki Sugioka and Yuko Umaba and Kozo Shishido",

note = "Funding Information: This work was supported in part by a Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology, Japan and Suntory Institute of Bioorganic Research. We thank Professor Y. Shinohara and Professor H. Terada for providing natural bongkrekic acid and Daiso Co. Ltd for supplying (S)-3-chloro-1,2-propandiol.",

year = "2004",

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doi = "10.1016/j.tetlet.2004.09.162",

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journal = "Tetrahedron Letters",

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T1 - Total synthesis of (+)-bongkrekic acid

AU - Shindo, Mitsuru

AU - Sugioka, Tomoyuki

AU - Umaba, Yuko

AU - Shishido, Kozo

N1 - Funding Information: This work was supported in part by a Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology, Japan and Suntory Institute of Bioorganic Research. We thank Professor Y. Shinohara and Professor H. Terada for providing natural bongkrekic acid and Daiso Co. Ltd for supplying (S)-3-chloro-1,2-propandiol.

PY - 2004/11/22

Y1 - 2004/11/22

N2 - Total synthesis of bongkrekic acid, an important apoptosis inhibitor, has been accomplished. The strategy includes inexpensive starting materials, asymmetric alkylation, anionic allyl coupling and oxidative manipulations. This process would provide a sufficient amount of bongkrekic acid and its analogues.

AB - Total synthesis of bongkrekic acid, an important apoptosis inhibitor, has been accomplished. The strategy includes inexpensive starting materials, asymmetric alkylation, anionic allyl coupling and oxidative manipulations. This process would provide a sufficient amount of bongkrekic acid and its analogues.

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DO - 10.1016/j.tetlet.2004.09.162

M3 - Article

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SP - 8863

EP - 8866

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 48

ER -

Total synthesis of (+)-bongkrekic acid

Abstract

All Science Journal Classification (ASJC) codes

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