Total synthesis and chemical biology of the sarcodictyins

K. C. Nicolaou, Jeffrey Pfefferkorn, Jinyou Xu, Nicolas Winssinger, Takashi Ohshima, Sanghee Kim, Seijiro Hosokawa, Dionisios Vourloumis, Floris Van Delft, Tianhu Li

Research output: Contribution to journalReview articlepeer-review

55 Citations (Scopus)


The sarcodictyins A - F and eleutherobin comprise a family of marine- derived diterpenoids with potent cytotoxicities against various tumor cell lines. Investigations have revealed that several of these compounds exert their cytotoxic effects through tubulin binding in a mechanism analogous to that of the clinical anticancer drug Taxol(TM). The biological importance, challenging molecular architecture, and relative scarcity of these natural products have prompted several groups to undertake their total chemical synthesis. In this review, we summarize the current synthetic efforts and examine the preliminary structure-activity relationships which have emerged from early combinatorial libraries.

Original languageEnglish
Pages (from-to)1199-1213
Number of pages15
JournalChemical and Pharmaceutical Bulletin
Issue number9
Publication statusPublished - Sept 1999
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General Chemistry
  • Drug Discovery


Dive into the research topics of 'Total synthesis and chemical biology of the sarcodictyins'. Together they form a unique fingerprint.

Cite this