TY - JOUR
T1 - Tooth Loss and Risk of Dementia in the Community
T2 - the Hisayama Study
AU - Takeuchi, Kenji
AU - Ohara, Tomoyuki
AU - Furuta, Michiko
AU - Takeshita, Toru
AU - Shibata, Yukie
AU - Hata, Jun
AU - Yoshida, Daigo
AU - Yamashita, Yoshihisa
AU - Ninomiya, Toshiharu
N1 - Funding Information:
We are grateful to the staff of the Division of Health and Welfare of the Hisayama Town Office for their cooperation in this study. Financial Disclosure: This study was supported in part by Grants-in-Aid for Scientific Research (A) (16H02644 and 16H02692), (B) (16H05850), and (C) (26350895, 26460748, 15K09267, 15K08738, 15K09835, and 16K09244) and Grant-in-Aid for Young Scientists (B) (15K20644) from the Ministry of Education, Culture, Sports, Science and Technology of Japan; by Health and Labour Sciences Research Grants of the Ministry of Health, Labour and Welfare of Japan (H25-Junkankitou [Seishuu]-Sitei-022, H26-Junkankitou [Seisaku]-Ippan-001, and H27-Shokuhin-[Sitei]-017); and by the Japan Agency for Medical Research and Development (AMED) (16dk0207025h0001, 16ek0210042h0002, and 16gm0610007h0204 (CREST)). Conflict of Interest: The authors have declared that they have no conflicts of interest exist. Author Contributions: Takeuchi: study concept and design, statistical analysis, interpretation of data, writing manuscript as principal author. Ohara: study concept and design, data collection, endpoint adjudication, statistical analysis, interpretation of data, writing and critical review of the manuscript. Furuta: data collection, statistical analysis, interpretation of data, critical review of manuscript. Takeshita, Shibata, Yoshida: data collection, interpretation of data, critical review of manuscript. Hata: data collection, endpoint adjudication, statistical analysis, interpretation of data, critical review of manuscript. Yamashita: study concept and design, interpretation of data, writing and critical review of the manuscript. Ninomiya: study coordination, study concept and design, data collection, endpoint adjudication, statistical analysis interpretation of data, writing and critical review of manuscript. All authors read and approved the final version of the manuscript. Sponsor's Role: The sponsors had no role in study design, conduct of study, data collection, data interpretation, or preparation of manuscript.
Publisher Copyright:
© 2017, The Authors. The Journal of the American Geriatrics Society published by Wiley Periodicals, Inc. on behalf of The American Geriatrics Society.
PY - 2017/5
Y1 - 2017/5
N2 - Objectives: To clarify the effect of tooth loss on development of all-cause dementia and its subtypes in an elderly Japanese population. Design: Prospective cohort study. Setting: The Hisayama Study, Japan. Participants: Community-dwelling Japanese adults without dementia aged 60 and older (N = 1,566) were followed for 5 years (2007–2012). Measurements: Participants were classified into four categories according to baseline number of remaining teeth (≥20, 10–19, 1–9, 0). The risk estimates of the effect of tooth loss on the development of all-cause dementia, Alzheimer's disease (AD), and vascular dementia (VaD) were computed using a Cox proportional hazards model. Results: During follow-up, 180 (11.5%) subjects developed all-cause dementia; 127 (8.1%) had AD, and 42 (2.7%) had VaD. After adjusting for potential confounders, there was a tendency for the multivariable-adjusted hazard ratio of all-cause dementia to increase with decrease in number of remaining teeth (P for trend =.04). The risk of all-cause dementia was 1.62 times as great in subjects with 10 to 19 teeth, 1.81 times as great in those with one to nine teeth, and 1.63 times as great in those with no teeth as in those with 20 teeth or more. An inverse association was observed between number of remaining teeth and risk of AD (P for trend =.08), but no such association was observed with risk of VaD (P for trend =.20). Conclusion: Tooth loss is associated with an increased risk of all-cause dementia and AD in the Japanese population.
AB - Objectives: To clarify the effect of tooth loss on development of all-cause dementia and its subtypes in an elderly Japanese population. Design: Prospective cohort study. Setting: The Hisayama Study, Japan. Participants: Community-dwelling Japanese adults without dementia aged 60 and older (N = 1,566) were followed for 5 years (2007–2012). Measurements: Participants were classified into four categories according to baseline number of remaining teeth (≥20, 10–19, 1–9, 0). The risk estimates of the effect of tooth loss on the development of all-cause dementia, Alzheimer's disease (AD), and vascular dementia (VaD) were computed using a Cox proportional hazards model. Results: During follow-up, 180 (11.5%) subjects developed all-cause dementia; 127 (8.1%) had AD, and 42 (2.7%) had VaD. After adjusting for potential confounders, there was a tendency for the multivariable-adjusted hazard ratio of all-cause dementia to increase with decrease in number of remaining teeth (P for trend =.04). The risk of all-cause dementia was 1.62 times as great in subjects with 10 to 19 teeth, 1.81 times as great in those with one to nine teeth, and 1.63 times as great in those with no teeth as in those with 20 teeth or more. An inverse association was observed between number of remaining teeth and risk of AD (P for trend =.08), but no such association was observed with risk of VaD (P for trend =.20). Conclusion: Tooth loss is associated with an increased risk of all-cause dementia and AD in the Japanese population.
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U2 - 10.1111/jgs.14791
DO - 10.1111/jgs.14791
M3 - Article
C2 - 28272750
AN - SCOPUS:85014623505
SN - 0002-8614
VL - 65
SP - e95-e100
JO - Journal of the American Geriatrics Society
JF - Journal of the American Geriatrics Society
IS - 5
ER -