TY - JOUR
T1 - Tissue distribution of cis- Diamminedichloroplatinum(II) following intraperitoneal administration to patients with recurrent gastric cancer
AU - Kusumoto, Tetsuya
AU - Maehara, Yoshihiko
AU - Sakaguchi, Yoshihisa
AU - Kakeji, Yoshihiro
AU - Nohzuka, Takayuki
AU - Furusawa, Motonosuke
AU - Sugimachi, Keizo
PY - 1993
Y1 - 1993
N2 - Using atomic absorption spectrophotometry, we determined the concentration of platinum in tissues obtained at autopsy of 4 patients with recurrent gastric cancer. Patients had been given intraperitoneal cis-diamminedichloro- platinum(II) (cisplatin, CDDP). There was no correlation between the con-centration of platinum and the dose of CDDP. Platinum was distributed in all organs examined, the highest amount being in the liver. Thus, when CDDP is administered intraperitoneally for treatment of patients with malignant disease, the toxicity to various organs, including the liver and the kidney, needs to be considered.
AB - Using atomic absorption spectrophotometry, we determined the concentration of platinum in tissues obtained at autopsy of 4 patients with recurrent gastric cancer. Patients had been given intraperitoneal cis-diamminedichloro- platinum(II) (cisplatin, CDDP). There was no correlation between the con-centration of platinum and the dose of CDDP. Platinum was distributed in all organs examined, the highest amount being in the liver. Thus, when CDDP is administered intraperitoneally for treatment of patients with malignant disease, the toxicity to various organs, including the liver and the kidney, needs to be considered.
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U2 - 10.1159/000227181
DO - 10.1159/000227181
M3 - Article
C2 - 8497372
AN - SCOPUS:0027273360
SN - 0030-2414
VL - 50
SP - 214
EP - 217
JO - Oncology (Switzerland)
JF - Oncology (Switzerland)
IS - 4
ER -
