TiO2 foams with poly-(d,l-lactic acid) (PDLLA) and PDLLA/Bioglass® coatings for bone tissue engineering scaffolds

Saša Novak; John Druce; Qi Zhi Chen; Aldo R. Boccaccini

doi:10.1007/s10853-008-2858-9

TiO₂ foams with poly-(d,l-lactic acid) (PDLLA) and PDLLA/Bioglass^® coatings for bone tissue engineering scaffolds

Saša Novak, John Druce, Qi Zhi Chen, Aldo R. Boccaccini

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

TiO₂ foam-like scaffolds with pore size ~300 μm and >95% porosity were fabricated by the foam replication method. A new approach to improve the structural integrity of the as-sintered foams, which exhibit extremely low compression strength, was explored by coating them with poly-(d,l-lactic acid) (PDLLA) or PDLLA/Bioglass^® layers. The PDLLA coating was shown to improve the mechanical properties of the scaffold: the compressive strength was increased by a factor of ~7. The composite coating involving Bioglass^® particles was shown to impart the rutile TiO₂ scaffold with the necessary bioactivity for the intended applications in bone tissue engineering. A dense hydroxyapatite layer formed on the surface of the foams upon immersion in simulated body fluid for 1 week.

Original language	English
Pages (from-to)	1442-1448
Number of pages	7
Journal	Journal of Materials Science
Volume	44
Issue number	6
DOIs	https://doi.org/10.1007/s10853-008-2858-9
Publication status	Published - Mar 2009
Externally published	Yes

All Science Journal Classification (ASJC) codes

Materials Science(all)
Mechanics of Materials
Mechanical Engineering

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10.1007/s10853-008-2858-9

Cite this

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title = "TiO2 foams with poly-(d,l-lactic acid) (PDLLA) and PDLLA/Bioglass{\textregistered} coatings for bone tissue engineering scaffolds",

abstract = "TiO2 foam-like scaffolds with pore size ~300 μm and >95% porosity were fabricated by the foam replication method. A new approach to improve the structural integrity of the as-sintered foams, which exhibit extremely low compression strength, was explored by coating them with poly-(d,l-lactic acid) (PDLLA) or PDLLA/Bioglass{\textregistered} layers. The PDLLA coating was shown to improve the mechanical properties of the scaffold: the compressive strength was increased by a factor of ~7. The composite coating involving Bioglass{\textregistered} particles was shown to impart the rutile TiO2 scaffold with the necessary bioactivity for the intended applications in bone tissue engineering. A dense hydroxyapatite layer formed on the surface of the foams upon immersion in simulated body fluid for 1 week.",

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AU - Novak, Saša

AU - Druce, John

AU - Chen, Qi Zhi

AU - Boccaccini, Aldo R.

PY - 2009/3

Y1 - 2009/3

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AB - TiO2 foam-like scaffolds with pore size ~300 μm and >95% porosity were fabricated by the foam replication method. A new approach to improve the structural integrity of the as-sintered foams, which exhibit extremely low compression strength, was explored by coating them with poly-(d,l-lactic acid) (PDLLA) or PDLLA/Bioglass® layers. The PDLLA coating was shown to improve the mechanical properties of the scaffold: the compressive strength was increased by a factor of ~7. The composite coating involving Bioglass® particles was shown to impart the rutile TiO2 scaffold with the necessary bioactivity for the intended applications in bone tissue engineering. A dense hydroxyapatite layer formed on the surface of the foams upon immersion in simulated body fluid for 1 week.

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TiO₂ foams with poly-(d,l-lactic acid) (PDLLA) and PDLLA/Bioglass^® coatings for bone tissue engineering scaffolds

Abstract

All Science Journal Classification (ASJC) codes

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