TY - JOUR
T1 - Time-dependent changes in the plasma amino acid concentration in diabetes mellitus
AU - Mochida, Taiga
AU - Tanaka, Takayuki
AU - Shiraki, Yasuko
AU - Tajiri, Hiroko
AU - Matsumoto, Shirou
AU - Shimbo, Kazutaka
AU - Ando, Toshihiko
AU - Nakamura, Kimitoshi
AU - Okamoto, Masahiro
AU - Endo, Fumio
N1 - Funding Information:
We thank the AJINOMOTO Co., Inc. for collaborating with us in this study. We thank the Center for Animal Resources and Development (CARD), Kumamoto University, for management of the animals used in this study. This work was supported in part by the Project for Realization of Regenerative Medicine from the Ministry of Education, Culture, Sports, Science and Technology (MEXT) Japan , the Advanced Education Program for Integrated Clinical, Basic and Social Medicine , Graduate School of Medical Sciences, Kumamoto University (Program for Enhancing Systematic Education in Graduate Schools, MEXT, Japan) and Grant-in-Aid for Scientific Resarch (MEXT, Japan). Pacific Edit reviewed the manuscript prior to submission.
PY - 2011/8
Y1 - 2011/8
N2 - We investigated longitudinal change in the amino acid (AA) profile in type 1 diabetes mellitus (DM) using AKITA mice, which develop DM as a result of insulin deficiency. The plasma concentrations of valine, leucine, isoleucine, as well as the total branched chain amino acids, alanine, citrulline and proline, were significantly higher in the diabetic mice. We show that the degree and timing of the changes were different among the plasma amino acid concentrations (pAAs) during the development of type 1 DM.
AB - We investigated longitudinal change in the amino acid (AA) profile in type 1 diabetes mellitus (DM) using AKITA mice, which develop DM as a result of insulin deficiency. The plasma concentrations of valine, leucine, isoleucine, as well as the total branched chain amino acids, alanine, citrulline and proline, were significantly higher in the diabetic mice. We show that the degree and timing of the changes were different among the plasma amino acid concentrations (pAAs) during the development of type 1 DM.
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U2 - 10.1016/j.ymgme.2011.05.002
DO - 10.1016/j.ymgme.2011.05.002
M3 - Article
C2 - 21636301
AN - SCOPUS:79960840896
SN - 1096-7192
VL - 103
SP - 406
EP - 409
JO - Molecular Genetics and Metabolism
JF - Molecular Genetics and Metabolism
IS - 4
ER -
