TY - JOUR
T1 - Three-dimensional molecular-field analyses of octopaminergic agonists for the cockroach neuronal octopamine receptor
AU - Hirashima, Akinori
AU - Morimoto, Masako
AU - Kuwano, Eiichi
AU - Eto, Morifusa
N1 - Funding Information:
This work was supported in part by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science, and Culture of Japan.
PY - 2003/8/15
Y1 - 2003/8/15
N2 - The quantitative structure-activity relationship of a set of 40 octopaminergic agonists against receptor 2 in cockroach nervous tissue, was analyzed using molecular-field analysis (MFA). MFA on the study set of those compounds evaluated effectively the energy between a probe and a molecular model at a series of points defined by a rectangular grid. Contour surfaces for the molecular fields were presented and the results provided useful information in the characterization and differentiation of octopaminergic receptor.
AB - The quantitative structure-activity relationship of a set of 40 octopaminergic agonists against receptor 2 in cockroach nervous tissue, was analyzed using molecular-field analysis (MFA). MFA on the study set of those compounds evaluated effectively the energy between a probe and a molecular model at a series of points defined by a rectangular grid. Contour surfaces for the molecular fields were presented and the results provided useful information in the characterization and differentiation of octopaminergic receptor.
UR - http://www.scopus.com/inward/record.url?scp=0041620625&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0041620625&partnerID=8YFLogxK
U2 - 10.1016/S0968-0896(03)00313-4
DO - 10.1016/S0968-0896(03)00313-4
M3 - Article
C2 - 12901920
AN - SCOPUS:0041620625
SN - 0968-0896
VL - 11
SP - 3753
EP - 3760
JO - Bioorganic and Medicinal Chemistry
JF - Bioorganic and Medicinal Chemistry
IS - 17
ER -