Three-dimensional magnetic nanoparticle imaging using small field gradient and multiple pickup coils

Teruyoshi Sasayama, Yuya Tsujita, Manabu Morishita, Masahiro Muta, Takashi Yoshida, Keiji Enpuku

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)


We propose a magnetic particle imaging (MPI) method based on third harmonic signal detection using a small field gradient and multiple pickup coils. First, we developed a system using two pickup coils and performed three-dimensional detection of two magnetic nanoparticle (MNP) samples, which were spaced 15 mm apart. In the experiments, an excitation field strength of 1.6 mT was used at an operating frequency of 3 kHz. A DC gradient field with a typical value of 0.2 T/m was also used to produce the so-called field-free line. A third harmonic signal generated by the MNP samples was detected using the two pickup coils, and the samples were then mechanically scanned to obtain field maps. The field maps were subsequently analyzed using the nonnegative least squares method to obtain three-dimensional position information for the MNP samples. The results show that the positions of the two MNP samples were estimated with good accuracy, despite the small field gradient used. Further improvement in MPI performance will be achieved by increasing the number of pickup coils used.

Original languageEnglish
Pages (from-to)144-150
Number of pages7
JournalJournal of Magnetism and Magnetic Materials
Publication statusPublished - Apr 1 2017

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics


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