Three-dimensional cell culture device utilizing thin membrane deformation by decompression

Takahisa Anada; Taisuke Masuda; Yoshitomo Honda; Junji Fukuda; Fumihito Arai; Toshio Fukuda; Osamu Suzuki

doi:10.1016/j.snb.2010.01.065

Three-dimensional cell culture device utilizing thin membrane deformation by decompression

Takahisa Anada, Taisuke Masuda, Yoshitomo Honda, Junji Fukuda, Fumihito Arai, Toshio Fukuda, Osamu Suzuki

Research output: Contribution to journal › Article › peer-review

52 Citations (Scopus)

Abstract

We have developed a novel multicellular aggregate (spheroid) culture device that utilizes thin polydimethylsiloxane membrane deformation by decompression. The device was capable of producing thousands of spheroids rapidly at a time and regulating the diameter of spheroids with narrow size distribution. The spheroids were easily retrieved from the device noninvasively. These characteristics of the device suggest that it has the potential for use in a wide variety of applications, such as drug screening and tissue engineering.

Original language	English
Pages (from-to)	376-379
Number of pages	4
Journal	Sensors and Actuators, B: Chemical
Volume	147
Issue number	1
DOIs	https://doi.org/10.1016/j.snb.2010.01.065
Publication status	Published - May 18 2010
Externally published	Yes

All Science Journal Classification (ASJC) codes

Instrumentation
Materials Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Electronic, Optical and Magnetic Materials
Condensed Matter Physics
Electrical and Electronic Engineering

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10.1016/j.snb.2010.01.065

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AU - Anada, Takahisa

AU - Masuda, Taisuke

AU - Honda, Yoshitomo

AU - Fukuda, Junji

AU - Arai, Fumihito

AU - Fukuda, Toshio

AU - Suzuki, Osamu

PY - 2010/5/18

Y1 - 2010/5/18

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AB - We have developed a novel multicellular aggregate (spheroid) culture device that utilizes thin polydimethylsiloxane membrane deformation by decompression. The device was capable of producing thousands of spheroids rapidly at a time and regulating the diameter of spheroids with narrow size distribution. The spheroids were easily retrieved from the device noninvasively. These characteristics of the device suggest that it has the potential for use in a wide variety of applications, such as drug screening and tissue engineering.

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Three-dimensional cell culture device utilizing thin membrane deformation by decompression

Abstract

All Science Journal Classification (ASJC) codes

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