Three-dimensional analysis of small airway with X-ray micro-CT

Toshihiro Sera, Yuji Hasegawa, Robert C. Schroter, Kazuo Tanishita

Research output: Contribution to journalConference articlepeer-review


To identify the anatomy of small airways, we visualized and quantified the excised rat lung at varying lung volume using the microfocus X-ray CT. We insufflated tantalum dust as contrast agent. Lung volume was varied in steps from functional residual capacity (FRC: 2 mL) to the maximal lung capacity (MLC: 12 mL). At FRC we found out airway closure in small airways (Maximum lumen area was 0.06 mm2 at MLC), where the bronchial walls are held in apposition. Lumen area dramatically varied at the first step during inflation and deflation, and the maximum area at MLC was 8 times as large as the minimum area at FRV.

Original languageEnglish
Pages (from-to)461-462
Number of pages2
JournalAmerican Society of Mechanical Engineers, Bioengineering Division (Publication) BED
Publication statusPublished - 2001
Externally publishedYes
EventProceedings of the 2001 Bioengineering Conference - Snowbird, UT, United States
Duration: Jun 27 2001Jul 1 2001

All Science Journal Classification (ASJC) codes

  • General Engineering


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