Thioredoxin1 as a negative regulator of cardiac hypertrophy

Tetsuro Ago, Junichi Sadoshima

Research output: Contribution to journalArticlepeer-review

49 Citations (Scopus)


Excessive reactive oxygen species (ROS) play an important role in the development of cardiac hypertrophy. In contrast, antioxidants scavenge ROS, thereby maintaining the reduced environment of cells and inhibiting hypertrophy in the heart. Thioredoxin1 (Trx1) not only functions as a major antioxidant in the heart but also interacts with important signaling molecules and transcription factors, thereby attenuating cardiac hypertrophy. This review will discuss the molecular mechanisms by which Trx1 exerts antihypertrophic effects in the heart.

Original languageEnglish
Pages (from-to)679-687
Number of pages9
JournalAntioxidants and Redox Signaling
Issue number6
Publication statusPublished - Jun 2007
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Physiology
  • Biochemistry
  • Clinical Biochemistry
  • Cell Biology


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