Thiazolobenzyne: A versatile intermediate for multisubstituted benzothiazoles

Suguru Yoshida, Takahisa Yano, Yoshitake Nishiyama, Yoshihiro Misawa, Masakazu Kondo, Takeshi Matsushita, Kazunobu Igawa, Katsuhiko Tomooka, Takamitsu Hosoya

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)


Thiazolobenzyne, which is a benzyne species fused with a thiazole ring, was efficiently generated via an iodine-magnesium exchange reaction of an ortho-iodoaryl triflate-type precursor using a trimethylsilylmethyl Grignard reagent as an activator. A wide range of arynophiles reacted efficiently with the thiazolobenzynes generated by this method to afford various multisubstituted benzothiazoles.

Original languageEnglish
Pages (from-to)11199-11202
Number of pages4
JournalChemical Communications
Issue number75
Publication statusPublished - 2016

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • General Chemistry
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry


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