Thermosensitive Polymer Biocompatibility Based on Interfacial Structure at Biointerface

Daiki Murakami, Yoko Kitahara, Shingo Kobayashi, Masaru Tanaka

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)


The interfacial structure of a thermosensitive biocompatible polymer, poly[2-(2-methoxyethoxy)ethyl methacrylate] (PMe2MA), at the polymer/phosphate-buffered saline (PBS) interface was investigated by atomic force microscopy. A number of nanometer scale protrusions appeared at 37 °C and disappeared at 22 °C, reversibly. This structural change occurred above the lower critical solution temperature of PMe2MA in PBS (19 °C), indicating that the formation of protrusions was explained by the microphase separation of polymer and water at the interfacial region. The protein adsorption and platelet adhesion onto PMe2MA interface were drastically restrained at 22 °C compared to that at 37 °C. Detachment of NIH3T3 cells accompanied by the dissipation of protrusions on the PMe2MA interface was also demonstrated. These results indicate that the protrusions act as the scaffold for the protein adsorption and cell adhesion.

Original languageEnglish
Pages (from-to)1591-1597
Number of pages7
JournalACS Biomaterials Science and Engineering
Issue number5
Publication statusPublished - May 14 2018

All Science Journal Classification (ASJC) codes

  • Biomaterials
  • Biomedical Engineering


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