TY - JOUR
T1 - Therapy-related chronic myelogenous leukaemia following autologous stem cell transplantation for Ewing's sarcoma
AU - Numata, Akihiko
AU - Shimoda, Kazuya
AU - Gondo, Hisashi
AU - Kato, Kouji
AU - Aoki, Kenichi
AU - Ito, Yoshikiyo
AU - Takase, Ken
AU - Asano, Yoshinobu
AU - Okamura, Takashi
AU - Niho, Yoshiyuki
AU - Harada, Mine
PY - 2002
Y1 - 2002
N2 - A 17-year-old Japanese woman with Ewing's sarcoma was initially treated with conventional chemotherapy and local irradiation, and then with high-dose chemotherapy supported by autologous peripheral blood stem cell transplantation. Four years later she was diagnosed with chronic myelogenous leukaemia (CML). The BCR/ABL fusion gene was detected in both peripheral blood and bone marrow cells by reverse transcription-polymerase chain reaction, but not in the harvest product of peripheral blood stem cells which were infused at the time of transplantation. This case adds to the accumulating evidence of therapy-related CML developing after high-dose chemotherapy and autologous stem cell transplantation.
AB - A 17-year-old Japanese woman with Ewing's sarcoma was initially treated with conventional chemotherapy and local irradiation, and then with high-dose chemotherapy supported by autologous peripheral blood stem cell transplantation. Four years later she was diagnosed with chronic myelogenous leukaemia (CML). The BCR/ABL fusion gene was detected in both peripheral blood and bone marrow cells by reverse transcription-polymerase chain reaction, but not in the harvest product of peripheral blood stem cells which were infused at the time of transplantation. This case adds to the accumulating evidence of therapy-related CML developing after high-dose chemotherapy and autologous stem cell transplantation.
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U2 - 10.1046/j.1365-2141.2002.03517.x
DO - 10.1046/j.1365-2141.2002.03517.x
M3 - Article
C2 - 12028029
AN - SCOPUS:18444389747
SN - 0007-1048
VL - 117
SP - 613
EP - 616
JO - British Journal of Haematology
JF - British Journal of Haematology
IS - 3
ER -