TY - JOUR
T1 - Therapeutic angiogenesis
T2 - Recent and future prospects of gene therapy in peripheral artery disease
AU - Tanaka, Michiko
AU - Taketomi, Kikuko
AU - Yonemitsu, Yoshikazu
N1 - Publisher Copyright:
© 2014 Bentham Science Publishers.
PY - 2014/9/1
Y1 - 2014/9/1
N2 - Peripheral artery disease (PAD) is a highly prevalent disease, which still has unmet medical needs. Therapeutic angiogenesis for PAD, achieved by gene therapy, has achieved promising results in preclinical studies and early-phase clinical trials, yet few late-phase clinical trials have been conducted or have not shown efficacy. This article provides an overview of the progression of angiogenesis research in gene therapy field as it applies to PAD. The focus of angiogenic growth factors and clinical trials is introduced as a frontier of therapeutic angiogenesis. The article also includes insights into future directions from bench to bedside.
AB - Peripheral artery disease (PAD) is a highly prevalent disease, which still has unmet medical needs. Therapeutic angiogenesis for PAD, achieved by gene therapy, has achieved promising results in preclinical studies and early-phase clinical trials, yet few late-phase clinical trials have been conducted or have not shown efficacy. This article provides an overview of the progression of angiogenesis research in gene therapy field as it applies to PAD. The focus of angiogenic growth factors and clinical trials is introduced as a frontier of therapeutic angiogenesis. The article also includes insights into future directions from bench to bedside.
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U2 - 10.2174/156652321404140902124838
DO - 10.2174/156652321404140902124838
M3 - Article
C2 - 25197884
AN - SCOPUS:84907152765
SN - 1566-5232
VL - 14
SP - 300
EP - 308
JO - Current Gene Therapy
JF - Current Gene Therapy
IS - 4
ER -