TY - JOUR
T1 - The Therapeutic Potential of Secreted Factors from Dental Pulp Stem Cells for Various Diseases
AU - Ogata, Kenichi
AU - Moriyama, Masafumi
AU - Nakamura, Seiji
AU - Matsumura-Kawashima, Mayu
AU - Kawado, Tatsuya
AU - Yano, Aiko
N1 - Funding Information:
This work was supported partly by Grants-in-Aid for Scientific Research (JP22K10221, JP20K18671 and JP20K23113) of the Ministry of Education, Culture, Sports, Science and Technology of Japan, including a research grant by SAITAS, Ikeda Scientific Co., ltd., and a research grant by The Uehara Memorial Foundation. Funding: This work was supported partly by Grants-in-Aid for Scientific Research (JP22K10221, JP20K18671 and JP20K23113) of the Ministry of Education, Culture, Sports, Science and Technology of Japan, including a research grant by SAITAS, Ikeda Scientific Co., ltd., and a research grant by The Uehara Memorial Foundation.
Publisher Copyright:
© 2022 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2022/5
Y1 - 2022/5
N2 - An alternative source of mesenchymal stem cells has recently been discovered: dental pulp stem cells (DPSCs), including deciduous teeth, which can thus comprise potential tools for regenerative medicine. DPSCs derive from the neural crest and are normally implicated in dentin homeostasis. The clinical application of mesenchymal stem cells (MSCs) involving DPSCs contains various limitations, such as high cost, low safety, and cell handling issues, as well as invasive sample collection procedures. Although MSCs implantation offers favorable outcomes on specific diseases, implanted MSCs cannot survive for a long period. It is thus considered that their mediated mechanism of action involves paracrine effects. It has been recently reported that secreted molecules in DPSCs-conditioned media (DPSC-CM) contain various trophic factors and cytokines and that DPSC-CM are effective in models of various diseases. In the current study, we focus on the characteristics of DPSC-CM and their therapeutic potential against various disorders.
AB - An alternative source of mesenchymal stem cells has recently been discovered: dental pulp stem cells (DPSCs), including deciduous teeth, which can thus comprise potential tools for regenerative medicine. DPSCs derive from the neural crest and are normally implicated in dentin homeostasis. The clinical application of mesenchymal stem cells (MSCs) involving DPSCs contains various limitations, such as high cost, low safety, and cell handling issues, as well as invasive sample collection procedures. Although MSCs implantation offers favorable outcomes on specific diseases, implanted MSCs cannot survive for a long period. It is thus considered that their mediated mechanism of action involves paracrine effects. It has been recently reported that secreted molecules in DPSCs-conditioned media (DPSC-CM) contain various trophic factors and cytokines and that DPSC-CM are effective in models of various diseases. In the current study, we focus on the characteristics of DPSC-CM and their therapeutic potential against various disorders.
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U2 - 10.3390/biomedicines10051049
DO - 10.3390/biomedicines10051049
M3 - Review article
AN - SCOPUS:85130050379
SN - 2227-9059
VL - 10
JO - Biomedicines
JF - Biomedicines
IS - 5
M1 - 1049
ER -