The T cell receptor β chain genes are located on chromosome 6 in mice and chromosome 7 in humans

Nicolette Caccia; Mitchell Kronenberg; Debra Saxe; Regina Haars; Gail A.P. Bruns; Joan Goverman; Marie Malissen; Hunt Willard; Yasunobu Yoshikai; Melvin Simon; Leroy Hood; Tak W. Mak

doi:10.1016/0092-8674(84)90443-4

The T cell receptor β chain genes are located on chromosome 6 in mice and chromosome 7 in humans

Nicolette Caccia, Mitchell Kronenberg, Debra Saxe, Regina Haars, Gail A.P. Bruns, Joan Goverman, Marie Malissen, Hunt Willard, Yasunobu Yoshikai, Melvin Simon, Leroy Hood, Tak W. Mak

Research output: Contribution to journal › Article › peer-review

132 Citations (Scopus)

Abstract

Homologous clones that encode the β chain of the T cell antigen receptor have been isolated recently from both murine and human cDNA libraries. These cDNA clones have been used in connection with interspecies hybrid cell lines to determine that the murine T cell receptor gene is located on chromosome 6 and the human gene on chromosome 7. In situ hybridization confirms these data and further localizes these genes to band B of chromosome 6 in the mouse and bands 7p13-21 in the human genome. The organization of the T cell antigen receptor J_β gene segments and C_β genes appears to be conserved, since very few intraspecies polymorphisms of restriction fragment length have been detected in either mouse or human DNA.

Original language	English
Pages (from-to)	1091-1099
Number of pages	9
Journal	Cell
Volume	37
Issue number	3
DOIs	https://doi.org/10.1016/0092-8674(84)90443-4
Publication status	Published - Jul 1984
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biochemistry, Genetics and Molecular Biology(all)

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10.1016/0092-8674(84)90443-4

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@article{ec943822a6ad4173bed3066f870d10b3,

title = "The T cell receptor β chain genes are located on chromosome 6 in mice and chromosome 7 in humans",

abstract = "Homologous clones that encode the β chain of the T cell antigen receptor have been isolated recently from both murine and human cDNA libraries. These cDNA clones have been used in connection with interspecies hybrid cell lines to determine that the murine T cell receptor gene is located on chromosome 6 and the human gene on chromosome 7. In situ hybridization confirms these data and further localizes these genes to band B of chromosome 6 in the mouse and bands 7p13-21 in the human genome. The organization of the T cell antigen receptor Jβ gene segments and Cβ genes appears to be conserved, since very few intraspecies polymorphisms of restriction fragment length have been detected in either mouse or human DNA.",

author = "Nicolette Caccia and Mitchell Kronenberg and Debra Saxe and Regina Haars and Bruns, {Gail A.P.} and Joan Goverman and Marie Malissen and Hunt Willard and Yasunobu Yoshikai and Melvin Simon and Leroy Hood and Mak, {Tak W.}",

note = "Funding Information: mouse-hamster hybrid cell lines and for helpful discussions, Dr. C. Blatt for testing some of the mouse strains for restriction fragment length polymorphisms, G. Siu and Dr. B. Toyonaga for testing some of the human DNA samples for restriction fragment length polymorphisms, and Connie Katz for preparation of the manuscript. This work was supported by grants from the Medical Research Council of Canada, the National Cancer Institute of Canada, National Institutes of Health grant HB 19658 (G. A. P.) and Public Health Service grant ROI GM29797-03 (M. S.).",

year = "1984",

month = jul,

doi = "10.1016/0092-8674(84)90443-4",

language = "English",

volume = "37",

pages = "1091--1099",

journal = "Cell",

issn = "0092-8674",

publisher = "Cell Press",

number = "3",

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TY - JOUR

T1 - The T cell receptor β chain genes are located on chromosome 6 in mice and chromosome 7 in humans

AU - Caccia, Nicolette

AU - Kronenberg, Mitchell

AU - Saxe, Debra

AU - Haars, Regina

AU - Bruns, Gail A.P.

AU - Goverman, Joan

AU - Malissen, Marie

AU - Willard, Hunt

AU - Yoshikai, Yasunobu

AU - Simon, Melvin

AU - Hood, Leroy

AU - Mak, Tak W.

N1 - Funding Information: mouse-hamster hybrid cell lines and for helpful discussions, Dr. C. Blatt for testing some of the mouse strains for restriction fragment length polymorphisms, G. Siu and Dr. B. Toyonaga for testing some of the human DNA samples for restriction fragment length polymorphisms, and Connie Katz for preparation of the manuscript. This work was supported by grants from the Medical Research Council of Canada, the National Cancer Institute of Canada, National Institutes of Health grant HB 19658 (G. A. P.) and Public Health Service grant ROI GM29797-03 (M. S.).

PY - 1984/7

Y1 - 1984/7

N2 - Homologous clones that encode the β chain of the T cell antigen receptor have been isolated recently from both murine and human cDNA libraries. These cDNA clones have been used in connection with interspecies hybrid cell lines to determine that the murine T cell receptor gene is located on chromosome 6 and the human gene on chromosome 7. In situ hybridization confirms these data and further localizes these genes to band B of chromosome 6 in the mouse and bands 7p13-21 in the human genome. The organization of the T cell antigen receptor Jβ gene segments and Cβ genes appears to be conserved, since very few intraspecies polymorphisms of restriction fragment length have been detected in either mouse or human DNA.

AB - Homologous clones that encode the β chain of the T cell antigen receptor have been isolated recently from both murine and human cDNA libraries. These cDNA clones have been used in connection with interspecies hybrid cell lines to determine that the murine T cell receptor gene is located on chromosome 6 and the human gene on chromosome 7. In situ hybridization confirms these data and further localizes these genes to band B of chromosome 6 in the mouse and bands 7p13-21 in the human genome. The organization of the T cell antigen receptor Jβ gene segments and Cβ genes appears to be conserved, since very few intraspecies polymorphisms of restriction fragment length have been detected in either mouse or human DNA.

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SN - 0092-8674

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JO - Cell

JF - Cell

IS - 3

ER -

The T cell receptor β chain genes are located on chromosome 6 in mice and chromosome 7 in humans

Abstract

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