The speckle tracking imaging for the assessment of cardiac resynchronization therapy (START) study

Takeshi Maruo; Yoshihiro Seo; Satoshi Yamada; Takeshi Arita; Tomoko Ishizu; Tsuyoshi Shiga; Kaoru Doh; Hiroyuki Toide; Azusa Furugen; Katsuji Inoue; Masao Daimon; Hiroya Kawai; Hikaru Tsuruta; Kazuhiro Nishigami; Satoshi Yuda; Tomoya Ozawa; Chisato Izumi; Yuko Fumikura; Yasuaki Wada; Mariko Doi; Masafumi Okada; Katsu Takenaka; Kazutaka Aonuma

doi:10.1253/circj.CJ-14-0842

The speckle tracking imaging for the assessment of cardiac resynchronization therapy (START) study

Takeshi Maruo, Yoshihiro Seo, Satoshi Yamada, Takeshi Arita, Tomoko Ishizu, Tsuyoshi Shiga, Kaoru Doh, Hiroyuki Toide, Azusa Furugen, Katsuji Inoue, Masao Daimon, Hiroya Kawai, Hikaru Tsuruta, Kazuhiro Nishigami, Satoshi Yuda, Tomoya Ozawa, Chisato Izumi, Yuko Fumikura, Yasuaki Wada, Mariko DoiMasafumi Okada, Katsu Takenaka, Kazutaka Aonuma

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26 Citations (Scopus)

Abstract

Background: We sought to identify the feasibility of speckle tracking echocardiography (STE) to predict cardiac resynchronization therapy (CRT) responders in a prospective multicenter study. Methods and Results: Patients who were newly implanted with a CRT device were enrolled. Time (T) from QRS to maximum peak radial and circumferential strain (CS) in 6 segments on the left ventricular (LV) short-axis plane, and to the maximum peak of longitudinal strain in 18 segments on 3 apical LV planes was measured (T_max). In segments with multiple peaks on the time-strain curves, time to the first peak (T_first) was also assessed. Difference in T between the earliest and latest segment and standard deviation (SD) of T in each strain component were assessed. CRT responders were defined as having LV end-systolic volume reduction >15% at 6 months after CRT. Clinical outcomes were assessed with a composite endpoint of death from cardiac causes or unplanned hospitalization for heart failure. Among 180 patients, 109 patients were identified as responders. T_first-SD of CS >116 ms was selected as the best independent predictor of CRT responders (P<0.001, hazard ratio=9.83, 95% confidence interval 3.78–25.6). In addition, T_first-SD of CS was associated with the clinical endpoints. Conclusions: This prospective multicenter study revealed the high feasibility of dyssynchrony assessment by STE, which may improve the ability to predict CRT responders.

Original language	English
Pages (from-to)	613-622
Number of pages	10
Journal	Circulation Journal
Volume	79
Issue number	3
DOIs	https://doi.org/10.1253/circj.CJ-14-0842
Publication status	Published - 2015

All Science Journal Classification (ASJC) codes

Cardiology and Cardiovascular Medicine

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10.1253/circj.CJ-14-0842

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Maruo, T., Seo, Y., Yamada, S., Arita, T., Ishizu, T., Shiga, T., Doh, K., Toide, H., Furugen, A., Inoue, K., Daimon, M., Kawai, H., Tsuruta, H., Nishigami, K., Yuda, S., Ozawa, T., Izumi, C., Fumikura, Y., Wada, Y., ... Aonuma, K. (2015). The speckle tracking imaging for the assessment of cardiac resynchronization therapy (START) study. Circulation Journal, 79(3), 613-622. https://doi.org/10.1253/circj.CJ-14-0842

Maruo, T, Seo, Y, Yamada, S, Arita, T, Ishizu, T, Shiga, T, Doh, K, Toide, H, Furugen, A, Inoue, K, Daimon, M, Kawai, H, Tsuruta, H, Nishigami, K, Yuda, S, Ozawa, T, Izumi, C, Fumikura, Y, Wada, Y, Doi, M, Okada, M, Takenaka, K & Aonuma, K 2015, 'The speckle tracking imaging for the assessment of cardiac resynchronization therapy (START) study', Circulation Journal, vol. 79, no. 3, pp. 613-622. https://doi.org/10.1253/circj.CJ-14-0842

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title = "The speckle tracking imaging for the assessment of cardiac resynchronization therapy (START) study",

abstract = "Background: We sought to identify the feasibility of speckle tracking echocardiography (STE) to predict cardiac resynchronization therapy (CRT) responders in a prospective multicenter study. Methods and Results: Patients who were newly implanted with a CRT device were enrolled. Time (T) from QRS to maximum peak radial and circumferential strain (CS) in 6 segments on the left ventricular (LV) short-axis plane, and to the maximum peak of longitudinal strain in 18 segments on 3 apical LV planes was measured (Tmax). In segments with multiple peaks on the time-strain curves, time to the first peak (Tfirst) was also assessed. Difference in T between the earliest and latest segment and standard deviation (SD) of T in each strain component were assessed. CRT responders were defined as having LV end-systolic volume reduction >15% at 6 months after CRT. Clinical outcomes were assessed with a composite endpoint of death from cardiac causes or unplanned hospitalization for heart failure. Among 180 patients, 109 patients were identified as responders. Tfirst-SD of CS >116 ms was selected as the best independent predictor of CRT responders (P<0.001, hazard ratio=9.83, 95% confidence interval 3.78–25.6). In addition, Tfirst-SD of CS was associated with the clinical endpoints. Conclusions: This prospective multicenter study revealed the high feasibility of dyssynchrony assessment by STE, which may improve the ability to predict CRT responders.",

author = "Takeshi Maruo and Yoshihiro Seo and Satoshi Yamada and Takeshi Arita and Tomoko Ishizu and Tsuyoshi Shiga and Kaoru Doh and Hiroyuki Toide and Azusa Furugen and Katsuji Inoue and Masao Daimon and Hiroya Kawai and Hikaru Tsuruta and Kazuhiro Nishigami and Satoshi Yuda and Tomoya Ozawa and Chisato Izumi and Yuko Fumikura and Yasuaki Wada and Mariko Doi and Masafumi Okada and Katsu Takenaka and Kazutaka Aonuma",

year = "2015",

doi = "10.1253/circj.CJ-14-0842",

language = "English",

volume = "79",

pages = "613--622",

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T1 - The speckle tracking imaging for the assessment of cardiac resynchronization therapy (START) study

AU - Maruo, Takeshi

AU - Seo, Yoshihiro

AU - Yamada, Satoshi

AU - Arita, Takeshi

AU - Ishizu, Tomoko

AU - Shiga, Tsuyoshi

AU - Doh, Kaoru

AU - Toide, Hiroyuki

AU - Furugen, Azusa

AU - Inoue, Katsuji

AU - Daimon, Masao

AU - Kawai, Hiroya

AU - Tsuruta, Hikaru

AU - Nishigami, Kazuhiro

AU - Yuda, Satoshi

AU - Ozawa, Tomoya

AU - Izumi, Chisato

AU - Fumikura, Yuko

AU - Wada, Yasuaki

AU - Doi, Mariko

AU - Okada, Masafumi

AU - Takenaka, Katsu

AU - Aonuma, Kazutaka

PY - 2015

Y1 - 2015

N2 - Background: We sought to identify the feasibility of speckle tracking echocardiography (STE) to predict cardiac resynchronization therapy (CRT) responders in a prospective multicenter study. Methods and Results: Patients who were newly implanted with a CRT device were enrolled. Time (T) from QRS to maximum peak radial and circumferential strain (CS) in 6 segments on the left ventricular (LV) short-axis plane, and to the maximum peak of longitudinal strain in 18 segments on 3 apical LV planes was measured (Tmax). In segments with multiple peaks on the time-strain curves, time to the first peak (Tfirst) was also assessed. Difference in T between the earliest and latest segment and standard deviation (SD) of T in each strain component were assessed. CRT responders were defined as having LV end-systolic volume reduction >15% at 6 months after CRT. Clinical outcomes were assessed with a composite endpoint of death from cardiac causes or unplanned hospitalization for heart failure. Among 180 patients, 109 patients were identified as responders. Tfirst-SD of CS >116 ms was selected as the best independent predictor of CRT responders (P<0.001, hazard ratio=9.83, 95% confidence interval 3.78–25.6). In addition, Tfirst-SD of CS was associated with the clinical endpoints. Conclusions: This prospective multicenter study revealed the high feasibility of dyssynchrony assessment by STE, which may improve the ability to predict CRT responders.

AB - Background: We sought to identify the feasibility of speckle tracking echocardiography (STE) to predict cardiac resynchronization therapy (CRT) responders in a prospective multicenter study. Methods and Results: Patients who were newly implanted with a CRT device were enrolled. Time (T) from QRS to maximum peak radial and circumferential strain (CS) in 6 segments on the left ventricular (LV) short-axis plane, and to the maximum peak of longitudinal strain in 18 segments on 3 apical LV planes was measured (Tmax). In segments with multiple peaks on the time-strain curves, time to the first peak (Tfirst) was also assessed. Difference in T between the earliest and latest segment and standard deviation (SD) of T in each strain component were assessed. CRT responders were defined as having LV end-systolic volume reduction >15% at 6 months after CRT. Clinical outcomes were assessed with a composite endpoint of death from cardiac causes or unplanned hospitalization for heart failure. Among 180 patients, 109 patients were identified as responders. Tfirst-SD of CS >116 ms was selected as the best independent predictor of CRT responders (P<0.001, hazard ratio=9.83, 95% confidence interval 3.78–25.6). In addition, Tfirst-SD of CS was associated with the clinical endpoints. Conclusions: This prospective multicenter study revealed the high feasibility of dyssynchrony assessment by STE, which may improve the ability to predict CRT responders.

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SN - 1346-9843

VL - 79

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EP - 622

JO - Circulation Journal

JF - Circulation Journal

IS - 3

ER -

The speckle tracking imaging for the assessment of cardiac resynchronization therapy (START) study

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