TY - JOUR
T1 - The Single and Double Blood Injection Rabbit Subarachnoid Hemorrhage Model
AU - Kikkawa, Yuichiro
AU - Kurogi, Ryota
AU - Sasaki, Tomio
N1 - Publisher Copyright:
© 2014, Springer Science+Business Media New York.
PY - 2014/2
Y1 - 2014/2
N2 - Over the past 30 years, the rabbit subarachnoid hemorrhage model (SAH) has been used for investigating the post-hemorrhage pathology, especially with respect to understanding of the mechanisms of cerebral vasospasm. However, the molecular mechanisms of cerebral vasospasm remain to be elucidated. Furthermore, it is not clear whether the rabbit SAH model is suitable for the investigation of pathological conditions other than cerebral vasospasm, such as early brain injury. Therefore, the properties of the rabbit SAH model need to be validated, and the reasons for using the rabbit should be clarified. This review explores the settings and technical issues of establishing a rabbit cisterna magna single and double blood injection SAH model and discusses the characteristics and feasibilities of the models.
AB - Over the past 30 years, the rabbit subarachnoid hemorrhage model (SAH) has been used for investigating the post-hemorrhage pathology, especially with respect to understanding of the mechanisms of cerebral vasospasm. However, the molecular mechanisms of cerebral vasospasm remain to be elucidated. Furthermore, it is not clear whether the rabbit SAH model is suitable for the investigation of pathological conditions other than cerebral vasospasm, such as early brain injury. Therefore, the properties of the rabbit SAH model need to be validated, and the reasons for using the rabbit should be clarified. This review explores the settings and technical issues of establishing a rabbit cisterna magna single and double blood injection SAH model and discusses the characteristics and feasibilities of the models.
KW - Animal model
KW - Cerebral vasospasm
KW - Cisterna magna
KW - Rabbit
KW - Subarachnoid hemorrhage
UR - http://www.scopus.com/inward/record.url?scp=84922074360&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84922074360&partnerID=8YFLogxK
U2 - 10.1007/s12975-014-0375-5
DO - 10.1007/s12975-014-0375-5
M3 - Review article
C2 - 25381219
AN - SCOPUS:84922074360
SN - 1868-4483
VL - 6
SP - 88
EP - 97
JO - Translational Stroke Research
JF - Translational Stroke Research
IS - 1
ER -