The Single and Double Blood Injection Rabbit Subarachnoid Hemorrhage Model

Yuichiro Kikkawa, Ryota Kurogi, Tomio Sasaki

Research output: Contribution to journalReview articlepeer-review

11 Citations (Scopus)

Abstract

Over the past 30 years, the rabbit subarachnoid hemorrhage model (SAH) has been used for investigating the post-hemorrhage pathology, especially with respect to understanding of the mechanisms of cerebral vasospasm. However, the molecular mechanisms of cerebral vasospasm remain to be elucidated. Furthermore, it is not clear whether the rabbit SAH model is suitable for the investigation of pathological conditions other than cerebral vasospasm, such as early brain injury. Therefore, the properties of the rabbit SAH model need to be validated, and the reasons for using the rabbit should be clarified. This review explores the settings and technical issues of establishing a rabbit cisterna magna single and double blood injection SAH model and discusses the characteristics and feasibilities of the models.

Original languageEnglish
Pages (from-to)88-97
Number of pages10
JournalTranslational Stroke Research
Volume6
Issue number1
DOIs
Publication statusPublished - Feb 2014

All Science Journal Classification (ASJC) codes

  • General Neuroscience
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

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