Objective: Disturbed sleep due to obstructive sleep apnea syndrome (OSAS) might accelerate amyloidβ (Aβ) deposition, which can be a crucial factor in Alzheimer’s disease. We studied Aβ deposition in untreated OSAS patients with normal cognition. Method: We performed polysomnography (PSG) and Aβ imaging with [11C]-Pittsburgh compound B PET computed tomography (11C-PiB PET CT) in 14 untreated OSAS patients (apnea–hypopnea index: 43.8 ± 26.3/h). Results: The abnormal accumulation of enhanced 11C-PiB PET was observed only one patient with severe, but not the most severe. Conclusions: The OSAS severity alone may not predict Aβ deposition in OSAS patients with normal cognition.
All Science Journal Classification (ASJC) codes
- Radiology Nuclear Medicine and imaging