The severity of obstructive sleep apnea syndrome cannot predict the accumulation of brain amyloid by imaging with [11C]-Pittsburgh compound B PET computed tomography in patients with a normal cognitive function

Sakiko Shimizu Handa; Shingo Baba; Kenichiro Yamashita; Mari Nishizaka; Shinichi Ando

doi:10.1007/s12149-019-01349-6

The severity of obstructive sleep apnea syndrome cannot predict the accumulation of brain amyloid by imaging with [11C]-Pittsburgh compound B PET computed tomography in patients with a normal cognitive function

Sakiko Shimizu Handa, Shingo Baba, Kenichiro Yamashita, Mari Nishizaka, Shinichi Ando

Radiology Center

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Objective: Disturbed sleep due to obstructive sleep apnea syndrome (OSAS) might accelerate amyloidβ (Aβ) deposition, which can be a crucial factor in Alzheimer’s disease. We studied Aβ deposition in untreated OSAS patients with normal cognition. Method: We performed polysomnography (PSG) and Aβ imaging with [¹¹C]-Pittsburgh compound B PET computed tomography (¹¹C-PiB PET CT) in 14 untreated OSAS patients (apnea–hypopnea index: 43.8 ± 26.3/h). Results: The abnormal accumulation of enhanced ¹¹C-PiB PET was observed only one patient with severe, but not the most severe. Conclusions: The OSAS severity alone may not predict Aβ deposition in OSAS patients with normal cognition.

Original language	English
Pages (from-to)	541-544
Number of pages	4
Journal	Annals of Nuclear Medicine
Volume	33
Issue number	7
DOIs	https://doi.org/10.1007/s12149-019-01349-6
Publication status	Published - Jul 1 2019

All Science Journal Classification (ASJC) codes

Radiology Nuclear Medicine and imaging

Access to Document

10.1007/s12149-019-01349-6

Fingerprint

Dive into the research topics of 'The severity of obstructive sleep apnea syndrome cannot predict the accumulation of brain amyloid by imaging with [11C]-Pittsburgh compound B PET computed tomography in patients with a normal cognitive function'. Together they form a unique fingerprint.

Cite this

Handa, S. S., Baba, S., Yamashita, K., Nishizaka, M., & Ando, S. (2019). The severity of obstructive sleep apnea syndrome cannot predict the accumulation of brain amyloid by imaging with [11C]-Pittsburgh compound B PET computed tomography in patients with a normal cognitive function. Annals of Nuclear Medicine, 33(7), 541-544. https://doi.org/10.1007/s12149-019-01349-6

The severity of obstructive sleep apnea syndrome cannot predict the accumulation of brain amyloid by imaging with [11C]-Pittsburgh compound B PET computed tomography in patients with a normal cognitive function. / Handa, Sakiko Shimizu; Baba, Shingo; Yamashita, Kenichiro et al.
In: Annals of Nuclear Medicine, Vol. 33, No. 7, 01.07.2019, p. 541-544.

Research output: Contribution to journal › Article › peer-review

Handa, SS, Baba, S, Yamashita, K, Nishizaka, M & Ando, S 2019, 'The severity of obstructive sleep apnea syndrome cannot predict the accumulation of brain amyloid by imaging with [11C]-Pittsburgh compound B PET computed tomography in patients with a normal cognitive function', Annals of Nuclear Medicine, vol. 33, no. 7, pp. 541-544. https://doi.org/10.1007/s12149-019-01349-6

@article{5907ed7eb2cf4963be5d6239c0fa913d,

title = "The severity of obstructive sleep apnea syndrome cannot predict the accumulation of brain amyloid by imaging with [11C]-Pittsburgh compound B PET computed tomography in patients with a normal cognitive function",

abstract = "Objective: Disturbed sleep due to obstructive sleep apnea syndrome (OSAS) might accelerate amyloidβ (Aβ) deposition, which can be a crucial factor in Alzheimer{\textquoteright}s disease. We studied Aβ deposition in untreated OSAS patients with normal cognition. Method: We performed polysomnography (PSG) and Aβ imaging with [11C]-Pittsburgh compound B PET computed tomography (11C-PiB PET CT) in 14 untreated OSAS patients (apnea–hypopnea index: 43.8 ± 26.3/h). Results: The abnormal accumulation of enhanced 11C-PiB PET was observed only one patient with severe, but not the most severe. Conclusions: The OSAS severity alone may not predict Aβ deposition in OSAS patients with normal cognition.",

author = "Handa, {Sakiko Shimizu} and Shingo Baba and Kenichiro Yamashita and Mari Nishizaka and Shinichi Ando",

note = "Publisher Copyright: {\textcopyright} 2019, The Japanese Society of Nuclear Medicine.",

year = "2019",

month = jul,

day = "1",

doi = "10.1007/s12149-019-01349-6",

language = "English",

volume = "33",

pages = "541--544",

journal = "Annals of Nuclear Medicine",

issn = "0914-7187",

publisher = "Springer Japan",

number = "7",

}

TY - JOUR

T1 - The severity of obstructive sleep apnea syndrome cannot predict the accumulation of brain amyloid by imaging with [11C]-Pittsburgh compound B PET computed tomography in patients with a normal cognitive function

AU - Handa, Sakiko Shimizu

AU - Baba, Shingo

AU - Yamashita, Kenichiro

AU - Nishizaka, Mari

AU - Ando, Shinichi

PY - 2019/7/1

Y1 - 2019/7/1

N2 - Objective: Disturbed sleep due to obstructive sleep apnea syndrome (OSAS) might accelerate amyloidβ (Aβ) deposition, which can be a crucial factor in Alzheimer’s disease. We studied Aβ deposition in untreated OSAS patients with normal cognition. Method: We performed polysomnography (PSG) and Aβ imaging with [11C]-Pittsburgh compound B PET computed tomography (11C-PiB PET CT) in 14 untreated OSAS patients (apnea–hypopnea index: 43.8 ± 26.3/h). Results: The abnormal accumulation of enhanced 11C-PiB PET was observed only one patient with severe, but not the most severe. Conclusions: The OSAS severity alone may not predict Aβ deposition in OSAS patients with normal cognition.

AB - Objective: Disturbed sleep due to obstructive sleep apnea syndrome (OSAS) might accelerate amyloidβ (Aβ) deposition, which can be a crucial factor in Alzheimer’s disease. We studied Aβ deposition in untreated OSAS patients with normal cognition. Method: We performed polysomnography (PSG) and Aβ imaging with [11C]-Pittsburgh compound B PET computed tomography (11C-PiB PET CT) in 14 untreated OSAS patients (apnea–hypopnea index: 43.8 ± 26.3/h). Results: The abnormal accumulation of enhanced 11C-PiB PET was observed only one patient with severe, but not the most severe. Conclusions: The OSAS severity alone may not predict Aβ deposition in OSAS patients with normal cognition.

UR - http://www.scopus.com/inward/record.url?scp=85063095906&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85063095906&partnerID=8YFLogxK

U2 - 10.1007/s12149-019-01349-6

DO - 10.1007/s12149-019-01349-6

M3 - Article

C2 - 30887231

AN - SCOPUS:85063095906

SN - 0914-7187

VL - 33

SP - 541

EP - 544

JO - Annals of Nuclear Medicine

JF - Annals of Nuclear Medicine

IS - 7

ER -

The severity of obstructive sleep apnea syndrome cannot predict the accumulation of brain amyloid by imaging with [11C]-Pittsburgh compound B PET computed tomography in patients with a normal cognitive function

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this