The serotonin1A receptor agonist 8-OHDPAT reverses Δ9-tetrahydrocannabinol-induced impairment of spatial memory and reduction of acetylcholine release in the dorsal hippocampus in rats

Keiichiro Inui; Nobuaki Egashira; Kenichi Mishima; Akiko Yano; Yoshiaki Matsumoto; Nobuyoshi Hasebe; Kohji Abe; Kazuhide Hayakawa; Tomoaki Ikeda; Katsunori Iwasaki; Michihiro Fujiwara

doi:10.1007/BF03033218

The serotonin_1A receptor agonist 8-OHDPAT reverses Δ⁹-tetrahydrocannabinol-induced impairment of spatial memory and reduction of acetylcholine release in the dorsal hippocampus in rats

Keiichiro Inui, Nobuaki Egashira, Kenichi Mishima, Akiko Yano, Yoshiaki Matsumoto, Nobuyoshi Hasebe, Kohji Abe, Kazuhide Hayakawa, Tomoaki Ikeda, Katsunori Iwasaki, Michihiro Fujiwara

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

Abstract

We studied the effects of 8-hydroxy-2-(di-n-propylamino) tetralin (8-OHDPAT), a 5-HT_1A receptor agonist, on both Δ₉-tetrahydrocannabinol-induced spatial memory impairment in an 8-arm radial maze, and the reduction of acetylcholine release in the dorsal hippocampus as assessed by in vivo microdialysis in rats. A 6 mg/kg i.p. dose of Δ⁹-tetrahydrocannabinol impaired spatial memory in the 8-arm radial maze and decreased the acetyl-choline release in the dorsal hippocampus. 8-OHD-PAT, at very low doses of 0.1-0.3 μg/kg, reversed both the impairment of spatial memory and the decrease in acetylcholine release induced by Δ⁹-tetrahydrocannabinol. These findings suggest that low doses of 8-OHDPAT may improve Δ⁹ -tetrahy-drocannabinol-induced impairment of spatial memory by enhancing acetylcholine release in the dorsal hippocampus.

Original language	English
Pages (from-to)	153-157
Number of pages	5
Journal	Neurotoxicity Research
Volume	6
Issue number	2
DOIs	https://doi.org/10.1007/BF03033218
Publication status	Published - 2004
Externally published	Yes

All Science Journal Classification (ASJC) codes

Neuroscience(all)
Toxicology

Access to Document

10.1007/BF03033218

Cite this

Inui, K., Egashira, N., Mishima, K., Yano, A., Matsumoto, Y., Hasebe, N., Abe, K., Hayakawa, K., Ikeda, T., Iwasaki, K., & Fujiwara, M. (2004). The serotonin_1A receptor agonist 8-OHDPAT reverses Δ⁹-tetrahydrocannabinol-induced impairment of spatial memory and reduction of acetylcholine release in the dorsal hippocampus in rats. Neurotoxicity Research, 6(2), 153-157. https://doi.org/10.1007/BF03033218

The serotonin_1A receptor agonist 8-OHDPAT reverses Δ⁹-tetrahydrocannabinol-induced impairment of spatial memory and reduction of acetylcholine release in the dorsal hippocampus in rats. / Inui, Keiichiro; Egashira, Nobuaki; Mishima, Kenichi et al.
In: Neurotoxicity Research, Vol. 6, No. 2, 2004, p. 153-157.

Research output: Contribution to journal › Article › peer-review

Inui, K, Egashira, N, Mishima, K, Yano, A, Matsumoto, Y, Hasebe, N, Abe, K, Hayakawa, K, Ikeda, T, Iwasaki, K & Fujiwara, M 2004, 'The serotonin_1A receptor agonist 8-OHDPAT reverses Δ⁹-tetrahydrocannabinol-induced impairment of spatial memory and reduction of acetylcholine release in the dorsal hippocampus in rats', Neurotoxicity Research, vol. 6, no. 2, pp. 153-157. https://doi.org/10.1007/BF03033218

@article{8cc78e16b39e4b7caea7c3f6ea76dd9e,

title = "The serotonin1A receptor agonist 8-OHDPAT reverses Δ9-tetrahydrocannabinol-induced impairment of spatial memory and reduction of acetylcholine release in the dorsal hippocampus in rats",

abstract = "We studied the effects of 8-hydroxy-2-(di-n-propylamino) tetralin (8-OHDPAT), a 5-HT1A receptor agonist, on both Δ9-tetrahydrocannabinol-induced spatial memory impairment in an 8-arm radial maze, and the reduction of acetylcholine release in the dorsal hippocampus as assessed by in vivo microdialysis in rats. A 6 mg/kg i.p. dose of Δ9-tetrahydrocannabinol impaired spatial memory in the 8-arm radial maze and decreased the acetyl-choline release in the dorsal hippocampus. 8-OHD-PAT, at very low doses of 0.1-0.3 μg/kg, reversed both the impairment of spatial memory and the decrease in acetylcholine release induced by Δ9-tetrahydrocannabinol. These findings suggest that low doses of 8-OHDPAT may improve Δ9 -tetrahy-drocannabinol-induced impairment of spatial memory by enhancing acetylcholine release in the dorsal hippocampus.",

author = "Keiichiro Inui and Nobuaki Egashira and Kenichi Mishima and Akiko Yano and Yoshiaki Matsumoto and Nobuyoshi Hasebe and Kohji Abe and Kazuhide Hayakawa and Tomoaki Ikeda and Katsunori Iwasaki and Michihiro Fujiwara",

note = "Funding Information: Part of this study was supported by a Grant-in-Aid for Scientific Research (No. 12771472) from the Ministry of Education, Science and Culture of Japan and the Research Grant (10A-3 and 13A-3) for Nervous and Mental Disorders from the Ministry of Health and Welfare. The authors are grateful to Professor Y. Shoyama, Department of Pharmacognosy, Graduate School of Pharmaceutical Sciences, Kyushu University, for his kind supply of natural D9-tetrahydrocannabinol.",

year = "2004",

doi = "10.1007/BF03033218",

language = "English",

volume = "6",

pages = "153--157",

journal = "Neurotoxicity Research",

issn = "1029-8428",

publisher = "Springer New York",

number = "2",

}

TY - JOUR

T1 - The serotonin1A receptor agonist 8-OHDPAT reverses Δ9-tetrahydrocannabinol-induced impairment of spatial memory and reduction of acetylcholine release in the dorsal hippocampus in rats

AU - Inui, Keiichiro

AU - Egashira, Nobuaki

AU - Mishima, Kenichi

AU - Yano, Akiko

AU - Matsumoto, Yoshiaki

AU - Hasebe, Nobuyoshi

AU - Abe, Kohji

AU - Hayakawa, Kazuhide

AU - Ikeda, Tomoaki

AU - Iwasaki, Katsunori

AU - Fujiwara, Michihiro

N1 - Funding Information: Part of this study was supported by a Grant-in-Aid for Scientific Research (No. 12771472) from the Ministry of Education, Science and Culture of Japan and the Research Grant (10A-3 and 13A-3) for Nervous and Mental Disorders from the Ministry of Health and Welfare. The authors are grateful to Professor Y. Shoyama, Department of Pharmacognosy, Graduate School of Pharmaceutical Sciences, Kyushu University, for his kind supply of natural D9-tetrahydrocannabinol.

PY - 2004

Y1 - 2004

N2 - We studied the effects of 8-hydroxy-2-(di-n-propylamino) tetralin (8-OHDPAT), a 5-HT1A receptor agonist, on both Δ9-tetrahydrocannabinol-induced spatial memory impairment in an 8-arm radial maze, and the reduction of acetylcholine release in the dorsal hippocampus as assessed by in vivo microdialysis in rats. A 6 mg/kg i.p. dose of Δ9-tetrahydrocannabinol impaired spatial memory in the 8-arm radial maze and decreased the acetyl-choline release in the dorsal hippocampus. 8-OHD-PAT, at very low doses of 0.1-0.3 μg/kg, reversed both the impairment of spatial memory and the decrease in acetylcholine release induced by Δ9-tetrahydrocannabinol. These findings suggest that low doses of 8-OHDPAT may improve Δ9 -tetrahy-drocannabinol-induced impairment of spatial memory by enhancing acetylcholine release in the dorsal hippocampus.

AB - We studied the effects of 8-hydroxy-2-(di-n-propylamino) tetralin (8-OHDPAT), a 5-HT1A receptor agonist, on both Δ9-tetrahydrocannabinol-induced spatial memory impairment in an 8-arm radial maze, and the reduction of acetylcholine release in the dorsal hippocampus as assessed by in vivo microdialysis in rats. A 6 mg/kg i.p. dose of Δ9-tetrahydrocannabinol impaired spatial memory in the 8-arm radial maze and decreased the acetyl-choline release in the dorsal hippocampus. 8-OHD-PAT, at very low doses of 0.1-0.3 μg/kg, reversed both the impairment of spatial memory and the decrease in acetylcholine release induced by Δ9-tetrahydrocannabinol. These findings suggest that low doses of 8-OHDPAT may improve Δ9 -tetrahy-drocannabinol-induced impairment of spatial memory by enhancing acetylcholine release in the dorsal hippocampus.

UR - http://www.scopus.com/inward/record.url?scp=4644226586&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=4644226586&partnerID=8YFLogxK

U2 - 10.1007/BF03033218

DO - 10.1007/BF03033218

M3 - Article

C2 - 15325968

AN - SCOPUS:4644226586

SN - 1029-8428

VL - 6

SP - 153

EP - 157

JO - Neurotoxicity Research

JF - Neurotoxicity Research

IS - 2

ER -

The serotonin_1A receptor agonist 8-OHDPAT reverses Δ⁹-tetrahydrocannabinol-induced impairment of spatial memory and reduction of acetylcholine release in the dorsal hippocampus in rats

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this