TY - JOUR
T1 - The role of the OVOL1–OVOL2 axis in normal and diseased human skin
AU - Tsuji, Gaku
AU - Ito, Takamichi
AU - Chiba, Takahito
AU - Mitoma, Chikage
AU - Nakahara, Takeshi
AU - Uchi, Hiroshi
AU - Furue, Masutaka
N1 - Funding Information:
This work was partly supported by grants from the Ministry of Health, Labour and Welfare, the Research on Development of New Drugs from the Japan Agency for Medical Research and Development (AMED) , and the Leading Advanced Projects for Medical Innovation (LEAP) .
Publisher Copyright:
© 2018 Japanese Society for Investigative Dermatology
PY - 2018/6
Y1 - 2018/6
N2 - OVOLs (OVO-like proteins) are ubiquitously conserved genes encoding a C 2 H 2 zinc finger transcription factor in mammals. Functional studies on OVOL1 and OVOL2 using knockout mice have suggested that these genes play a pivotal role in the development of epithelial tissues arising from germ cells; however, the role of the OVOL1–OVOL2 axis in normal and diseased tissues remains unclear. This review highlights recent advances in understanding how the OVOL1–OVOL2 axis modulates cell differentiation and proliferation in human keratinocytes, hair follicles, and benign or malignant skin tumors including squamous cell carcinoma and malignant melanoma. Furthermore, OVOL1 has been shown to be involved in the expression of skin barrier proteins including filaggrin (FLG), and its mutation or dysfunction leads to the development of atopic dermatitis (AD). OVOL1 has also been identified as a susceptibility gene for AD by genome-wide association studies, in addition to FLG. Therefore, we discuss the relationship between OVOL1 and FLG in the development of AD.
AB - OVOLs (OVO-like proteins) are ubiquitously conserved genes encoding a C 2 H 2 zinc finger transcription factor in mammals. Functional studies on OVOL1 and OVOL2 using knockout mice have suggested that these genes play a pivotal role in the development of epithelial tissues arising from germ cells; however, the role of the OVOL1–OVOL2 axis in normal and diseased tissues remains unclear. This review highlights recent advances in understanding how the OVOL1–OVOL2 axis modulates cell differentiation and proliferation in human keratinocytes, hair follicles, and benign or malignant skin tumors including squamous cell carcinoma and malignant melanoma. Furthermore, OVOL1 has been shown to be involved in the expression of skin barrier proteins including filaggrin (FLG), and its mutation or dysfunction leads to the development of atopic dermatitis (AD). OVOL1 has also been identified as a susceptibility gene for AD by genome-wide association studies, in addition to FLG. Therefore, we discuss the relationship between OVOL1 and FLG in the development of AD.
UR - http://www.scopus.com/inward/record.url?scp=85042018177&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85042018177&partnerID=8YFLogxK
U2 - 10.1016/j.jdermsci.2018.02.005
DO - 10.1016/j.jdermsci.2018.02.005
M3 - Review article
C2 - 29454536
AN - SCOPUS:85042018177
SN - 0923-1811
VL - 90
SP - 227
EP - 231
JO - Journal of Dermatological Science
JF - Journal of Dermatological Science
IS - 3
ER -
